What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lariam (Mefloquine)
Prescription Required
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Product Details
Description
Lariam is used to treat and prevent malaria.
Lariam is available in 250 mg oral tablets.
Directions
Take Lariam for malaria exactly as prescribed by your doctor. If you have any questions or concerns, talk to your doctor or pharmacist.
Malaria treatment:
- Adults - Take 5 tablets (1250 mg) by mouth one time with food and a full glass of water.
- Pediatrics - 20-25 mg per kg of body weight. Split into two doses and separate by 6-8 hours.
Malaria prevention:
- Adults - 250 mg by mouth once weekly.
- Pediatrics - 5 mg per kg of body weight once weekly.
- 45 kg or more - 250 mg
- 30-45 kg - ¾ tablet
- 20-30 kg - ½ tablet
Ingredients
The active ingredient in Lariam is mefloquine hydrochloride. Inactive ingredients include ammonium-calcium alginate, corn starch, crospovidone, lactose, magnesium stearate, microcrystalline cellulose, poloxamer #331, and talc.
Contraindications
Lariam should not be taken by patients who are allergic to any of its ingredients.
Lariam should not be used for malaria prevention in patients with active depression, a recent history of depression, generalized anxiety disorder, psychosis, or schizophrenia or other major psychiatric disorders, or with a history of convulsions.
Cautions
- Lariam contains the following warnings:
- Patients with life-threatening, serious, or overwhelming malaria infections caused by P. falciparum should receive an intravenous antimalarial drug. Lariam may be given to complete the course of therapy after the intravenous treatment is complete.
- Halofantrine should not be taken with Lariam or within 15 weeks of the last dose of Lariam. Taking these two medications together can cause a potentially fatal heart arrhythmia that results in prolongation of the QTc interval.
- Ketoconazole should not be taken with Lariam or within 15 weeks of the last dose of Lariam. Taking these two medications together can cause a potentially fatal heart arrhythmia that results in prolongation of the QTc interval.
- Lariam levels in the body can be increased by ketoconazole.
- Anxiety, paranoia, depression, hallucinations, psychotic behavior, and other psychiatric symptoms can be caused by Lariam. These symptoms can continue after Lariam has been discontinued. Sucidal ideation and suicide has occurred; however, a relationship to drug administration has not been confirmed. Patients with active depression or with a recent history of depression, generalized anxiety disorder, psychosis, or schizophrenia or other major psychiatric disorders should not take Lariam for malaria prevention. Caution should be used in patients who have had depression.
- If acute anxiety, depression, restlessness, confusion, or other psychiatric symptoms occur when taking Lariam for malaria prevention, the medication should be stopped and an alternative medication should be started.
- Taking Lariam with quinine or quinidine may result in electrocardiographic abnormalities.
- Taking Lariam with quinine or chloroquine may increase the risk of convulsions.
- Before you start taking Lariam, tell your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Do not drive or operate machinery until you know how Lariam affects you.
- Caution should be used in patients with liver problems.
- Elevated liver function tests and eye problems may occur with long-term use of Lariam.
- Lariam should only be used in patients with heart disease if the benefits outweigh the risks.
Side Effects
Vomiting is the most common Lariam side effect. However, other side effects may also occur. Contact your doctor right away if you have side effects that bother you or won’t go away.
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Reference
- Lariam. Nutley, NJ: Roche Laboratories Inc.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1597
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