Lapelga (Pegfilgrastim)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Lapelga (pegfilgrastim) is an injectable prescription medication that helps the bone marrow make infection-fighting white blood cells. It is used to treat low counts of neutrophils, a certain type of white blood cell, in certain cancer patients who are being treated with chemotherapy that reduces the production of white blood cells.
Lapelga (pegfilgrastim) injection is available in 6 mg/0.6 mL single-dose prefilled syringes.
Fact Table
Formula
C845H1343N223O243S9
License
US FDA
Bioavailability
60-70%
Legal status
Prescription only
Chemical Name
Pegfilgrastim
Elimination half-life
15-80 hours
Dosage (Strength)
6 mg/0.6 mL
Pregnancy
Consult a doctor
Brands
Neulasta, Nyvepria, Ziextenzo, Lapelga
Protein binding
N/A
PubChem CID
91942286
MedlinePlus
a604002
ChEBI
63718
ATC code
L03AA13
DrugBank
DB00019
KEGG
D06464
Routes of administration
Subcutaneous
Directions
A healthcare provider will teach you or your caregiver how to use Lapelga, including preparation, administration, and disposal. Lapelga is given as an injection underneath the skin.
Do not share needles or syringes with other people.
For detailed instructions, refer to the medication guide that comes with your prescription. If you have any questions or concerns, talk to your healthcare provider or pharmacist.
Storing Lapelga:
Store Lapelga in the refrigerator away from light. Do not freeze or shake hard. If you accidentally freeze the medication, let it thaw in the refrigerator before using. Throw it away if it is frozen 2 times or if it is left at room temperature for longer than 24 hours.
Ingredients
The active ingredient in Lapelga is pegfilgrastim. Inactive ingredients include 10 mM acetate, 5% sorbitol, 0.004% polysorbate 20, and water for injection to total of 0.6 mL; pH: 4.0.
Contraindications
Patients with an allergy to any of Lapelga’s ingredients or products made using the bacteria E. coli should not receive the medication.
Cautions
- Before you begin treatment with Lapelgla, talk to a healthcare provider about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Lapelga may cause the following conditions:
- Bleeding due to decreased number of platelets. Immediately inform your healthcare provider of any signs of bleeding, including nose bleeds, unexplained bruising, and black or tarry stools.
- Capillary leak syndrome. Immediately seek medical care of any swelling, trouble breathing, abdominal swelling, tiredness, or feeling full.
- Lung problems, including acute respiratory distress syndrome
- Ruptured spleen. Immediately call your healthcare provider if you experience pain in the left upper stomach or left upper shoulder.
- Sickle cell disease
- Increased risk of bone marrow disorders and certain types of leukemia in people with breast or lung cancer. Immediately inform your healthcare provider of any fever, bone pain, bruising, trouble breathing, or bleeding that you experience.
- The safety of using Lapelga with chemotherapy that kills cells has not been determined. Do not use Lapelga within 14 days before or 24 hours after chemotherapy. Additionally, the safety and efficacy of using Lapelga after certain chemotherapies such as mitomycin C, 5-fluorouracil, and nitrosoureas, has not been determined.
- The safety and efficacy of using Lapelga with radiation has not been determined; therefore, it is not recommended to use Lapelga during radiation.
- Lapelga’s needle cover contains latex. Consult with your healthcare provider before use if you are allergic to latex.
- Lapelga should not be used during pregnancy unless the benefits outweigh the risks.
- If you are breastfeeding, consult with your healthcare provider before using Lapelga, as it may affect your baby.
- It is not known whether Lapelga is safe and effective in children.
Side Effects
Pain of the bone and muscle, redness, swelling, and itching at the injection site are some Lapelga side effects. However, other side effects may also occur. Immediately inform your healthcare provider of side effects that bother you or won’t go away.
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Reference:
Lapelga. MedBroadcast.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14441
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