What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Kynmobi (Apomorphine HCI) Sublingual film
Prescription Required
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Product Details
Description
Kynmobi (apomorphine hydrochloride) is used to treat acute, intermittent “off” episodes in patients who have Parkinson's Disease.
Fact Table
Formula
C17H17NO2
License
US DailyMed
Bioavailability
100%
Legal status
Rx-Only
Chemical Name
Apomorphine HCI
Elimination half-life
40 minutes
Dosage (Strength)
10mg - 50mg
Pregnancy
Consult Doctor
Brands
Kynmobi
Protein binding
50%
PubChem CID
6005
MedlinePlus
a604020
ChEBI
48538
ATC code
G04BE07
DrugBank
DB00714
KEGG
D07460
Routes of administration
Subcutaneous injection
Directions
Follow the instructions that come with your prescription. If you have any questions or concerns about your prescription, talk to your doctor or pharmacist. Your doctor may also prescribe a medication to help prevent nausea and vomiting that can occur with Kynmobi.
Kynmobi is available as a sublingual film in the following strengths: 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg.
Each Kynmobi film should be placed under the tongue. The films should not be cut, chewed, or swallowed.
The typical dose is between 10 mg and 30 mg per dose as needed. Each dose should be separated by 2 hours or more. No more than 5 doses should be administered per day. No more than 30 mg should be taken at one time.
Ingredients
Apomorphine hydrochloride is the active ingredient contained in Kynmobi.
Contraindications
Do not take Kynmobi with medications known as 5HT3 antagonists. These include ondansetron, granisetron, dolasetron, palonosetron, and alosetron. Ask your doctor if you are unsure whether or not you take 5HT3 antagonists.
Do not take Kynmobi if you are allergic to apomorphine, sodium metabisulfite, or any of the other ingredients or excipients contained in Kynmobi.
Cautions
- Before you start taking Kynmobi, be sure to tell your doctor:
- About the medications you take. These include prescription, nonprescription, vitamins, and herbal supplements.
- About your allergies.
- About your health problems.
- About your pregnancy status. Kynmobi may cause harm to an unborn baby.
- About your breastfeeding status. It is not known whether or not Kynmobi is transferred into breast milk.
- If you drink alcohol.
- Kynmobi can cause nausea and vomiting.
- Kynmobi can cause you to feel drowsy or fall asleep during the daytime or during normal activities. Do not drive or operate machinery until you know how the Kynmobi affects you.
- Kynmobi can cause low blood pressure. Your blood pressure should be monitored during treatment with Kynmobi.
- Kynmobi can cause irritation to the inside of your mouth. Tell your doctor if this occurs. Your doctor may decide to pause or stop your treatment with Kynmobi.
- Kynmobi can increase your risk for falls.
- Kynmobi can cause hallucinations and psychosis. Tell your doctor right away if these occur.
- Kynmobi can cause impulsive behaviors. Tell your doctor right away if you experience impulsive behaviors or intense urges to gamble, spend money, or other urges.
- Suddenly stopping or decreasing the dose of Kynmobi can cause withdrawal-emergent hyperpyrexia and confusion with symptoms such as fever, muscle stiffness, altered mental status, autonomic instability, and increased serum creatine kinase levels.
- Kynmobi can cause QTc prolongation that can lead to torsades de pointes or death. Talk to your doctor about risk factors for QT prolongation.
Side Effects
The most common side effects of Kynmobi include nausea, dizziness, drowsiness, and mouth irritation, pain, and tingling. Kynmobi can cause other side effects as well. Contact your doctor right away if you experience side effects that bother you or won't go away.
Reference:
Kynmobi (apomorphine hydrochloride) sublingual film. Marlborough, MA: Sunovion Pharmaceuticals Inc.; 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13649
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