Koselugo (Selumetinib)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Koselugo (selumetinib) is a medication prescribed to treat pediatric patients who are 2+ years old with neurofibromatosis type 1 (NF1) and have inoperable plexiform neurofibromas that are causing symptoms.
Koselugo is dispensed in 10 mg and 25 mg capsules for oral administration.
Directions
Koselugo should be taken as prescribed by the treating physician.
The capsules may be taken with or without food. Patients with liver problems may require a lower dosage.
For further usage instructions, you may refer to the medication guide that comes with the Koselugo prescription.
Contact the pharmacist or treating physician about any questions or concerns that arise.
Ingredients
The active ingredient in Koselugo is selumetinib.
Inactive ingredients in the 10 mg capsule include vitamin E polyethylene glycol succinate, hypromellose, carrageenan, potassium chloride, titanium dioxide, carnauba wax, purified water, shellac, iron oxide black, propylene glycol, and ammonium hydroxide.
Inactive ingredients in the 25 mg capsule include vitamin E polyethylene glycol succinate, hypromellose, carrageenan, potassium chloride, titanium dioxide, FD&C blue 2, ferric oxide yellow, purified water, carnauba wax and/or cornstarch, ferric oxide red, ferric oxide yellow, FD&C Blue 2 aluminum lake, shellac, and glyceryl monooleate.
Contraindications
According to the most recent Prescribing Information, there are no contraindications.
Cautions
- Before patients begin treatment with Koselugo, the following should be discussed with the treating physician:
- All the medications the patient takes, including prescription and over-the-counter medications
- The patient’s allergies
- The patient’s current health problems and past medical history
- If the patient is pregnant or breastfeeding
- Koselugo contains the following warnings and precautions:
- Cardiomyopathy
- Eye problems
- Stomach/intestinal problems
- Skin problems
- Increased creatine phosphokinase and rhabdomyolysis, which is the breakdown of muscle tissue that releases harmful proteins into the blood
- Increased vitamin E and bleeding risk
Side Effects
Vomiting, rash, abdominal pain, diarrhea, nausea, dry skin, fatigue, musculoskeletal pain, fever, acneiform rash, stomatitis, headache, nail inflammation/infection, and itching are the most common Koselugo side effects; however, other side effects may also occur.
Patients should contact a doctor right away if they have side effects that bother them or won’t go away.
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Reference
- Koselugo. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14944
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