Korsuva (Difelikefalin)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Korsuva (difelikefalin) is administered intravenously to treat adults with moderate to severe itching caused by chronic kidney disease and who are receiving hemodialysis (HD).
Fact Table
Formula
C36H53N7O6
License
US FDA
Bioavailability
Not applicable (IV administration)
Legal status
Prescription only (Rx)
Chemical Name
Difelikefalin
Elimination half-life
23-31 hours
Dosage (Strength)
0.5 mg/mL in a single-dose vial
Pregnancy
Consult a doctor
Brands
Korsuva
Protein binding
~25%
PubChem CID
57384877
MedlinePlus
a621046
ChEBI
CHEBI:171243
ATC code
V03AX04
DrugBank
DB05519
KEGG
D10973
Routes of administration
Intravenous (IV)
Directions
Your doctor will determine an appropriate treatment regimen for you. A healthcare provider will administer Korsuva via an intravenous (IV) injection at the end of each HD treatment.
If you have any questions or concerns, talk to your doctor.
Ingredients
The active ingredient in Korsuva is difelikefalin.
Contraindications
Korsuva does not have any contraindications per the most recent Prescribing Information. Ask your doctor whether Korsuva may be an appropriate treatment for you.
Cautions
- Before you begin Korsuva treatment, tell your doctor about:
- All the prescription and over-the-counter medications you use
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Korsuva is associated with several warnings and precautions:
- Dizziness, drowsiness, altered mental status, and problems with walking
- Impaired mental or physical abilities to safely drive, operate machinery, or participate in other dangerous activities; therefore, patients should avoid these activities until they know how the medication affects them
- Patients with severe liver problems are not recommended to receive Korsuva therapy.
Side Effects
Dizziness, diarrhea, nausea, problems with walking, falls, high potassium levels in the blood, headache, drowsiness, and altered mental status are common side effects of Korsuva. Immediately notify your doctor if you experience side effects that bother you or won’t go away.
Ask your doctor about Korsuva injection.
Reference
Korsuva. Stamford, CT: Cara Therapeutics, Inc.; 2021.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13783
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