What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ketorolac (Tromethamine)
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Product Details
Description
Ketorolac uses may include the treatment of severe or general pain management. Your doctor may prescribe it for the short-term or long-term treatment of pain.
Fact Table
Formula
C15H13NO3
License
EU EMA, US FDA
Bioavailability
80–100%
Legal status
Rx-only
Chemical Name
tromethamine
Elimination half-life
3.5 h to 9.2 h
Dosage (Strength)
10mg
Pregnancy
not recommended
Brands
Ketorolac
Protein binding
99%
PubChem CID
3826
MedlinePlus
a693001
ChEBI
6129
ATC code
M01AB15
DrugBank
DB00465
KEGG
D08104
Routes of administration
By mouth
Directions
The most common directions for this medication are 10 mg by mouth every 4-6 hours as needed for pain, not to exceed 40 mg per day.
Ketorolac should only be taken for the shortest amount of time at the lowest possible dose.
Ingredients
The active ingredient in ketorolac is ketorolac tromethamine.
Interactions
Common drug-drug interactions with ketorolac include the following:
- Acemetacin
- Aminolevulinic Acid
- Apixaban
- Aspirin
- Bemiparin
- CycloSPORINE
- Dabigatran Etexilate
- Edoxaban
- Enoxaparin
- Heparin
- Ketorolac (nasal)
- Lithium
- Loop diuretics
- Macimorelin
- Methotrexate
- Mifamurtide
- Nonsteroidal anti-inflammatory agents
- Pentoxifylline
- Phenylbutazone
- PRALAtrexate
- Probenecid
- Rivaroxaban
- Salicylates
- Selective serotonin reuptake inhibitors
- Sincalide
- Sodium phosphates
- Tenofovir products
- Tenoxicam
- Urokinase
- Vitamin K antagonists
Please tell your doctor or pharmacist if you are taking any of the above
Cautions
Tell your doctor if you have a history of stomach problems, liver problems, or kidney problems. This medication may be unsafe in certain people with these conditions.
Do not take this medicine with other non-steroidal anti-inflammatory drugs (NSAIDs) because it can increase the risk of stomach bleeds.
Side Effects
A list of potential ketorolac side effects can include:
- Abdominal pain
- Alopecia
- Anemia
- Anorexia
- Asthma
- Blurred vision
- Cardiac failure
- Constipation
- Cough
- Cystitis
- Diaphoresis
- Diarrhea
- Dizziness
- Drowsiness
- Dyspepsia
- Dysuria
- Ecchymoses
- Edema
- Esophagitis
- Exacerbation of urinary frequency
- Fever
- Flatulence
- Gastritis
- Gastrointestinal fullness
- Gastrointestinal hemorrhage
- Gastrointestinal perforation
- Gastrointestinal ulcer
- Headache
- Heartburn
- Hematemesis
- Hematuria
- Hepatitis
- Hypertension
- Increased appetite
- Increased liver enzymes
- Increased thirst
- Infertility
- Jaundice
- Melena
- Nausea
- Oliguria
- Pallor
- Palpitations
- Prolonged bleeding time
- Proteinuria
- Pruritus
- Purpuric disease
- Renal function abnormality
- Skin photosensitivity
- Skin rash
- Stomatitis
- Syncope
- Tachycardia
- Tinnitus
- Urinary retention
- Urticaria
- Vomiting
- Weight changes
References
Ketorolac (Tromethamine)Nutley, NJ: Roche Laboratories Inc.; 2008.Frequently Asked Questions about Ketorolac
What is Ketorolac?
Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and inflammation. It is available in various forms, including oral tablets, injectable solutions, and eye drops.
What conditions is Ketorolac used to treat?
Ketorolac is typically prescribed to manage moderate to severe pain, such as postoperative pain, musculoskeletal pain, and pain related to certain medical procedures. It can also be used as an ophthalmic solution to treat eye pain and inflammation.
How does Ketorolac work?
Ketorolac works by reducing the production of chemicals called prostaglandins, which are responsible for pain and inflammation. By inhibiting prostaglandin production, Ketorolac helps alleviate pain and reduce swelling.
What are the common side effects of Ketorolac?
Common side effects of Ketorolac may include nausea, vomiting, stomach pain, diarrhea, dizziness, headache, and swelling or pain at the injection site (if administered as an injection). It is important to discuss potential side effects with your healthcare provider.
Can Ketorolac be used for long-term pain management?
Ketorolac is generally not recommended for long-term use due to the risk of serious side effects. It is typically prescribed for short-term pain relief, such as after surgery or injury. Your healthcare provider will determine the appropriate duration of treatment.
Can I take Ketorolac with other medications?
It's important to inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements. Ketorolac may interact with certain medications, and your healthcare provider can advise you on potential drug interactions.
How should I take Ketorolac?
The dosing instructions for Ketorolac can vary depending on the form (oral, injectable, or ophthalmic) and the condition being treated. Always follow your healthcare provider's instructions carefully and do not exceed the recommended dose.
What should I do if I miss a dose of Ketorolac?
If you miss a dose of Ketorolac, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take extra doses to make up for a missed one.
Is it safe to drink alcohol while taking Ketorolac?
Drinking alcohol while taking Ketorolac can increase the risk of stomach irritation and bleeding. It's generally best to avoid alcohol or limit its consumption while using this medication.
Can Ketorolac be addictive?
Ketorolac is not considered addictive, as it does not produce the euphoria or craving associated with some other pain medications. However, it should be used only as prescribed by your healthcare provider to minimize the risk of misuse.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 1590
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