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Jevtana (Cabazitaxel)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Jevtana is used to treat patients with prostate cancer who were previously treated with a regimen that consisted of docetaxel.


    Fact Table

    Formula

    C45H57NO14

    License

    US DailyMed, US FDA, EU EMA

    Bioavailability

    56.6%

    Legal status

    Rx-Only

    Chemical Name

    Cabazitaxel

    Elimination half-life

    95 hours

    Dosage (Strength)

    -

    Pregnancy

    Consult Doctor

    Brands

    Jevtana

    Protein binding

    89% to 92%

    PubChem CID

    9854073

    MedlinePlus

    a611009

    ChEBI

    63584

    ATC code

    L01CD04

    DrugBank

    DB06772

    KEGG

    D09755

    Routes of administration

    Intravenous

    Directions

    Any questions or concerns about Jevtana may be referred to your doctor.

    Your doctor or other qualified healthcare provider will administer your Jevtana and instruct you on how often you should receive the intravenous infusion.

    Ingredients

    The active ingredient in Jevtana is cabazitaxel. The inactive ingredients include polysorbate 80 and citric acid monohydrate.

    Contraindications

    Jevtana should not be administered to patients with an allergy to the medication or to polysorbate 80, severe liver problems, or blood cell counts that are 1500/mm3 or less.

    Cautions

    Jevtana contains the following FDA Boxed Warnings:

    • Neutropenic deaths have occurred. Blood counts should be obtained frequently. Jevtana should not be administered to patients with neutrophil counts that are 1,500/mm3 or less. High-risk patients or patients receiving 25 mg/m2 of Jevtana may receive primary prophylaxis with G-CSF.
    • Jevtana can cause severe allergic reactions that result in rash, redness, low blood pressure, and difficulty breathing. Jevtana should be stopped and appropriate therapy initiated if a patient experiences any of these effects.
    • Patients with severe allergic reactions to cabazitaxel or other drugs that contain polysorbate 80 should not receive Jevtana.
    • Before you begin receiving Jevtana, tell your doctor about:
    • All the prescription and over-the-counter medications you take
    • Your allergies
    • Your current health conditions and past medical history
    • Your pregnancy or breastfeeding status
    • Abnormal blood counts and bone marrow suppression can occur with Jevtana use. Blood counts should be frequently obtained.
    • Patients who are 65 years of age and older may be at increased risk for toxicities, which can be fatal or cause serious adverse reactions.
    • Nausea, vomiting, and diarrhea can occur. Death associated with diarrhea has occurred.
    • Kidney failure, liver problems, urinary disorders, and respiratory disorders can occur.
    • Jevtana can cause harm to an unborn baby or cause loss of pregnancy. Effective contraceptive methods should be used.

    Side Effects

    Abnormal cell counts, anemia, diarrhea, nausea, fatigue, weakness, vomiting, blood in the urine, constipation, decreased appetite, back pain, and stomach pain are common Jevtana side effects. However, these are not the only side effects that can occur. Call your doctor right away if you have side effects that bother you or won’t go away.

    Reference

    Jevtana. Bridgewater, NJ: sanofi-aventis U.S. LLC; 2021.



    Dr Savannah Muncy
    About Dr. Savannah Muncy (Page Author)


    Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13939

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