What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Januvia (Sitagliptin Phosphate)
Also Known as Istavel
Generic Equivalent - Januvia (Sitagliptin Phosphate)
Prescription Required
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Product Details
Description
JANUVIA (Sitagliptin phosphate) is a medication used to treat type 2 diabetes mellitus. It should be as an adjunct to diet and exercise. JANUVIA should not be prescribed for type 1 diabetes mellitus or the treatment or diabetic ketoacidosis.
JANUVIA works by inhibiting the enzyme DPP-4 in the gastrointestinal tract. DPP-4 normally shuts off incretin hormones, and incretin hormones are responsible for promoting the digestion process and increasing the release of insulin. By blocking DPP-4, JANUVIA increases the activity of incretin hormones, causing a downstream increase in insulin. The net effect is to lower blood sugar.
Combined with diet and exercise, JANUVIA has been shown to decrease hemoglobin A1C, fasting plasma glucose (FPG), and 2-hour postprandial glucose (PPG).
Directions
Take JANUVIA 100 mg once daily with or without food.
The dose may be reduced to 25-50 mg once daily in patients with kidney problems.
Ingredients
The active ingredient in JANUVIA is sitagliptin.
Fact Table
Formula
C16H15F6N5O
License
EU EMA, US FDA
Bioavailability
87%
Legal status
RX Only
Chemical Name
Sitagliptin Phosphate
Elimination half-life
8-14 hours
Dosage (Strength)
25mg (28 or 84 tablets), 50mg (28 or 84 tablets), 100mg (28 or 84 tablets)
Pregnancy
Consult a doctor
Brands
Januvia
Protein binding
38%
PubChem CID
4369359
MedlinePlus
a606023
ChEBI
40237
ATC code
A10BH01
DrugBank
DB01261
KEGG
D08516
Routes of administration
By mouth (tablets)
Cautions
After it's market release, there have been reports of pancreatitis. Speak with your doctor if you have a personal or family history of pancreatitis.
During JANUVIA therapy, heart function should be monitored for patients at risk of heart failure. It should be used with caution or discontinued in those with active heart failure.
Patients with renal impairment or renal failure should use caution when taking JANUVIA.
JANUVIA has been known to cause rare and serious skin conditions. If you notice a skin reaction while taking JANUVIA, stop taking it and let your doctor know.
Speak with your doctor for a full list of warnings and precautions.
Side Effects
The most common side effects of JANUVIA are:
- Upper respiratory infection
- Nasopharyngitis
- Headache
Buy JANUVIA online with a valid prescription from a doctor. Canada Pharmacy has Competitive Januvia Prices.
References
- Januvia [package insert].Whitehouse Station, NJ: Merck, 2019
Frequently Asked Questions about Januvia (Sitagliptin)
What are the serious side effects of Januvia?
Serious side effects of Januvia may include pancreatitis, heart failure, kidney problems, allergic reactions, severe joint pain, and bullous pemphigoid.
What is the most common side effect of Sitagliptin?
The most common side effects of Januvia include upper respiratory infection, stuffy or runny nose, and sore throat.
What is the major side effect of Januvia?
The major side effects of Januvia include pancreatitis, heart failure, and kidney problems.
Is Januvia bad for your kidneys?
Januvia has been associated with kidney problems, including cases requiring dialysis. If you have kidney issues, consult your doctor before taking Januvia.
Does Januvia cause weight gain?
Weight gain is not a common side effect of Januvia. However, individual responses may vary.
How long can you take Januvia?
The duration of Januvia use depends on your specific medical condition and your doctor’s recommendations. Follow your healthcare provider’s guidance.
Can Januvia be stopped abruptly?
It’s essential to consult your doctor before discontinuing Januvia. Abruptly stopping any medication can have consequences. Your doctor will guide you on the appropriate approach.
Is it better to take Januvia in the morning or at night?
Januvia is usually taken once a day, and the timing can vary. Some people take it in the morning, while others take it at night. Follow your doctor’s instructions for the best results.
What to avoid while taking Januvia?
While taking Januvia, avoid excessive alcohol consumption. Otherwise, there are no specific dietary restrictions. Always follow your doctor’s advice.
Is Metformin and Januvia the same?
No, they're different. Metformin improves how insulin works and lowers liver glucose production for diabetes. Januvia boosts insulin release and lowers blood sugar as a DPP-4 inhibitor.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9461
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