What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Invega Sustenna Injection (Paliperidone Palmitate)
Prescription Required
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Product Details
Description
Invega Sustenna is a prescription medication for treating psychiatric disorders, specifically schizophrenia, bipolar disorder, and schizoaffective disorder. It is a long-acting injectable (LAI) antipsychotic that works for 28 days.
Invega Sustenna works by alleviating symptoms and improving the overall quality of life for individuals affected by these conditions.
Fact Table
Formula
C23H27FN4O3
License
EU EMA, US FDA
Bioavailability
28%
Legal status
Rx-only
Chemical Name
Paliperidone
Elimination half-life
23 hours
Dosage (Strength)
3mg, 6mg, 9mg
Pregnancy
Consult Doctor
Brands
Invega
Protein binding
74%
PubChem CID
115237
MedlinePlus
a607005
ChEBI
82978
ATC code
N05AX13
DrugBank
DB01267
KEGG
D05339
Routes of administration
By mouth
Directions
Invega Sustenna is administered through a once-monthly injection given by a healthcare provider.
The injection is given into the deltoid or gluteal muscle.
The usual monthly dosage is 39-234 mg once monthly.
Ingredients
The active ingredient is paliperidone.
During the first month, an injection is given on day 1, day 8, and then on day 29.
Interactions
Common drug-drug interactions with Invega Sustenna may include the following:
- Amobarbital
- Bosentan
- Butalbital
- Carbamazepine
- Carbamazepine
- Cimetidine
- Clarithromycin
- Diltiazem
- Domperidone
- Donepezil
- Efavirenz
- Erythromycin
- Ethallobarbital
- Fluconazole
- Grapefruit juice
- Griseofulvin
- Itraconazole
- Ketoconazole
- Mephobarbital
- Methadone
- Methohexital
- Modafinil
- Nevirapine
- Ondansetron
- Pentobarbital
- Phenobarbital
- Phenytoin
- QT-prolonging drugs
- Quinine
- Rifampicin
- Ritonavir
- Secobarbital
- St. John's wort
- Talbutal
- Thiopental
- Tramadol
- Verapamil
Cautions
Before starting Invega Sustenna, tell your doctor about any kidney or liver problems.
Your doctor should regularly monitor the levels of blood cells during the course of this medication.
Tell your doctor if you have a history of seizures.
This drug may cause hyperprolactinemia which can lead to gynecomastia or the painful enlargement of breasts.
Tell your doctor if you have a history of heart problems, diabetes, or any other chronic medical conditions.
Use caution if you are taking other drugs that treat mental health disorders.
Side Effects
The most common side effects of this drug are:
- Akathisia (restlessness)
- Anxiety
- Constipation
- Dizziness
- Drowsiness
- Dry mouth
- Extrapyramidal symptoms (movement disorders)
- Headache
- Increased heart rate
- Insomnia
- Nausea
- Orthostatic hypotension (low blood pressure upon standing)
- Rash or skin reactions
- Weight gain
References
- Invega Sustenna [package insert]. Titusville, NJ: Janssen; 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11338
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