What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Inhibace Plus (Cilazapril/HCTZ)
Generic Equivalent - Inhibace Plus (Cilazapril/HCTZ)
Prescription Required
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Product Details
Description
Your doctor may prescribe Inhibace Plus to control high blood pressure (hypertension). It includes cilazapril, an ACE inhibitor, and hydrochlorothiazide (HCTZ), a diuretic. Lowering blood pressure with Inhibace Plus helps decrease the risk of strokes, heart attacks, and kidney issues.
Cilazapril helps to relax blood vessels, easing the heart's workload. Hydrochlorothiazide promotes the removal of excess salt and water through urine, further lowering blood pressure.
Fact Table
Formula
C22H31N3O5 (Cilazapril) + C7H8ClN3O4S2 (HCTZ)
License
EMA
Bioavailability
60% (Cilazapril) + 70% (HCTZ)
Legal status
Prescription only (Rx)
Chemical Name
(Cilazapril) 1-[2S-[1[R*(R*)],2[R*]]-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-proline
(HCTZ) 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxideElimination half-life
9 hours (Cilazaprilat) + 6-15 hours (HCTZ)
Dosage (Strength)
5 mg Cilazapril + 12.5 mg HCTZ tablets
Pregnancy
Contraindicated
Brands
Inhibace Plus
Protein binding
30% (Cilazaprilat) + 40-68% (HCTZ)
PubChem CID
60730 (Cilazapril) + 3639 (HCTZ)
MedlinePlus
a693005
ChEBI
CHEBI:48815 (Cilazapril) + CHEBI:5778 (HCTZ)
ATC code
C09BA08
DrugBank
DB01340 (Cilazapril) + DB00999 (HCTZ)
KEGG
D01841 (Cilazapril) + D00360 (HCTZ)
Routes of administration
Oral
Directions
The dosage of Inhibace Plus varies from person to person. Take it exactly as prescribed.
Ingredients
Inhibace Plus is a combination drug that includes cilazapril and hydrochlorothiazide.
Interactions
Common drug-drug interactions may include:
- Acarbose
- Allopurinol
- Alogliptin
- Amantadine
- Amphotericin B
- Antiarrhythmics
- Atenolol
- Atropine
- Benazepril
- Betaxolol
- Bisoprolol
- Canagliflozin
- Captopril
- Carbamazepine
- Carvedilol
- Cyclosporine
- Dapagliflozin
- Digoxin
- Dulaglutide
- Empagliflozin
- Enalapril
- Ertugliflozin
- Everolimus
- Exenatide
- Fosinopril
- Glimepiride
- Glipizide
- Glyburide
- Hydrochlorothiazide
- Insulin aspart
- Insulin detemir
- Insulin glargine
- Insulin lispro
- Labetalol
- Linagliptin
- Liraglutide
- Lisinopril
- Lithium
- Metformin
- Metoprolol
- Miglitol
- Moexipril
- Nadolol
- Nateglinide
- Nebivolol
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Perindopril
- Pioglitazone
- Potassium supplements
- Propranolol
- Quinapril
- Ramipril
- Repaglinide
- Rosiglitazone
- Saxagliptin
- Semaglutide
- Sirolimus
- Sitagliptin
- Sotalol
- Thiazolidinediones
- Timolol
- Topiramate
Cautions
Before beginning Inhibace Plus, notify your doctor if you have a history of kidney or liver conditions, electrolyte disturbances, or gout.
Avoid Inhibace Plus if you have allergies to cilazapril, hydrochlorothiazide, or any of the medication's ingredients.
Side Effects
The most common side effects are:
- Acute interstitial pneumonitis
- Acute pulmonary edema
- Anaphylaxis
- Arrhythmia
- Cholestatic jaundice
- Cutaneous vasculitis
- Dehydration
- Depression
- Dizziness
- Dry mouth
- Fatigue
- Granulocytopenia
- Gout
- Hemolytic anaemia
- Hypercalcaemia
- Hypercholesterolaemia (increased total, LDL, and VLDL cholesterol)
- Hyperglycaemia
- Hypertriglyceridaemia
- Hyperuricaemia
- Hypersensitivity (angioedema, anaphylaxis)
- Hypochloraemia
- Hypocalciuria
- Hypokalemia
- Hyponatremia
- Hypotension
- Hypovolaemia
- Hypomagnesaemia
- Interstitial nephritis
- Lacrimation decreased
- Liver enzyme levels above the reference range
- Loss of appetite
- Metabolic alkalosis
- Muscle cramp
- Nausea
- Photosensitivity
- Pseudoporphyria
- Rash
- Renal impairment
- Sexual dysfunction
- Sialoadenitis
- Sleep disorder
- Thrombocytopaenia
- Visual impairment
References
Apo-cilazapril/HCTZ [product monograph]. Toronto, ON: Apotex; November 2017.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10449
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