What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Ibsrela (Tenapanor)
Prescription Required
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Product Details
Description
Ibsrela, also known as Tenapanor, is a medication that helps adults with a condition called irritable bowel syndrome with constipation (IBS-C). This condition can cause stomach pain and difficulty with bowel movements. The Ibsrela mechanism of action involves blocking a specific protein in the gut that normally helps absorb salt. By doing this, it allows more water to stay in the intestines, which helps increase bowel movements and reduce pain. It comes in tablet form.
Fact Table
Formula
C50H66F9N9O10S2
License
US FDA
Bioavailability
Minimal (negligible systemic absorption)
Legal status
Prescription only (Rx)
Chemical Name
2-[[[2-[(2S)-2-[[(1R)-1-[5-(aminosulfonyl)-2-fluorophenyl]-1-hydroxy-2-(methylamino)ethyl]amino]-2-phenylacetyl]amino]acetyl]amino]methyl]-4-[4-(trifluoromethyl)phenyl]methyl]phenyl]butanoic acid
Elimination half-life
Unknown (minimal systemic exposure)
Dosage (Strength)
50 mg tablets
Pregnancy
Consult a doctor (Category Not Assigned)
Brands
Ibsrela
Protein binding
>99%
PubChem CID
25035845
MedlinePlus
a619039
ChEBI
145514
ATC code
A06AX07
DrugBank
DB12047
KEGG
D10801
Routes of administration
Oral
Directions
Ibsrela is typically taken orally once before breakfast and dinner. Each tablet contains 50 mg of the active ingredient Tnapanor. Swallow the tablet whole and avoid crushing, chewing, or breaking it. Stick to the prescribed dosage and do not adjust it unless directed by a healthcare provider.
Ingredients
Ibsrela contains the active ingredient Tenapanor.
Contraindications
Avoid taking or using Dapsone if any of the following apply:
- Individuals under 6 years of age due to the risk of serious dehydration
- Patients with known or suspected mechanical gastrointestinal obstruction
- Anyone with a history of hypersensitivity to Tenapanor or any component of the product
Cautions
- Before beginning treatment with Ibsrela, it's important to discuss the following with your healthcare provider:
- Your current health conditions
- Any allergies you may have
- All medications you are currently using
- Whether you are pregnant or breastfeeding
- Ibsrela is not suitable for children under 6 years old due to serious risks of dehydration that can be fatal. The safety and effectiveness of Ibsrela in people under 18 years old have not been confirmed.
- For children between 6 to 12 years old, the use of Ibsrela should be avoided. While there's no specific data for this age group, the severe risks noted in younger rats suggest a cautious approach.
- Diarrhea is a common side effect of Ibsrela, and it can sometimes be severe. If you experience severe diarrhea, it's important to stop taking the medication temporarily and focus on rehydrating.
Side Effects
Ibsrela may cause side effects. The most frequent side effect is diarrhea, which may be severe at times. If you experience intense diarrhea, it's important to stop taking Ibsrela and consult your doctor immediately. Other common side effects include abdominal swelling or a sensation of fullness, gas, and dizziness.
If the diarrhea becomes severe or you experience other persistent and bothersome side effects, seek medical advice promptly. These side effects, while typically manageable, may affect your daily activities and overall health.
References
- Ibsrela (Tenapanor) Product Monograph. Waltham, MA: Ardelyx, Inc,; 2022.
- Ibsrela (Tenapanor) Drug Label Information. Waltham, MA: Ardelyx, Inc,; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14959
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