Humira (Adalimumab)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Humira is a type of medication called a monoclonal antibody. It is a prescription drug that can target specific proteins in the body that lead to autoimmune disease. The following conditions can be treated with Humira:
- Ankylosing spondylitis
- Crohn disease
- Hidradenitis suppurativa
- Plaque psoriasis
- Psoriatic arthritis
- Rheumatoid arthritis
- Ulcerative colitis
- Uveitis
Humira works by binding to TNF-alpha, a protein free-floating in the blood. Normally, TNF-alpha activates many different immune system cells. For people with the above conditions, they have too much activity in their immune system. Humira helps to lower that activity back to normal.
Fact Table
Formula
C6428H9912N1694O1987S46
License
US FDA, EU EMA
Bioavailability
64%
Legal status
Rx-Only
Chemical Name
Adalimumab
Elimination half-life
3 hour
Dosage (Strength)
-
Pregnancy
not recommended
Brands
Humira
Protein binding
Not Available
PubChem CID
Not Available
MedlinePlus
a603010
ChEBI
Not Available
ATC code
L04AB04
DrugBank
DB00051
KEGG
D02597
Routes of administration
Subcutaneous
Directions
The directions for Humira are determined by your healthcare provider. The Humira dosage varies based on what condition is being treated.
Use Humira exactly as prescribed by your healthcare provider.
Humira should be stored in the refrigerator at 36°F to 46°F (2°C to 8°C), and not in the freezer. If brought to room temperature, Humira will last for 14 days.
Ingredients
Adalimumab is the active ingredient in Humira.
Interactions
Serious drug-drug interactions with Humira include:
- Abatacept
- Anakinra
- BCG
- Certolizumab
- Echinacea
- Fingolimod
- Inactivated vaccines
- Leflunomide
- Live vaccines
- Natalizumab
- Pimecrolimus
- Sipuleucel-T
- Tacrolimus
- Tocilizumab
- Vedolizumab
Cautions
Tell your doctor if you have a history of cardiovascular disease or heart failure before taking Humira.
Tell your doctor if you have a latent infection like hepatitis B or tuberculosis. Humira can reactivate these infections.
Humira may increase the risk of certain cancers.
This list is not a full list of the possible precautions while taking Humira. Ask your doctor or pharmacist for precautions that are applicable to you.
Side Effects
Common Humira side effects may include:
- Antibody development
- Headache
- Increase creatinine phosphokinase
- Infections
- Injection site reaction
- Positive autoantibody titer
- Sinusitis
- Skin rash
- Upper respiratory tract infection
References
- Humira [package insert].Chicago, IL: Abbvie; 2020.
Frequently Asked Questions about Humira (Adalimumab)
What is Humira (Adalimumab)?
Humira (Adalimumab) is a prescription medication used to treat various autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, and more. It belongs to a class of drugs called TNF blockers.
How does Humira work?
Humira works by targeting and neutralizing a protein called tumor necrosis factor alpha (TNF-alpha). TNF-alpha plays a key role in inflammation, and by blocking it, Humira helps reduce inflammation and alleviate symptoms associated with autoimmune diseases.
What conditions are treated with Humira?
Humira is prescribed to manage and treat autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, hidradenitis suppurativa, juvenile idiopathic arthritis, plaque psoriasis, and more. It is important to consult with a healthcare provider to determine if Humira is the right treatment for your specific condition.
How is Humira administered?
Humira is typically administered by subcutaneous injection (under the skin). The frequency of injections and dosage can vary depending on the condition being treated. Healthcare providers will provide detailed instructions on how to administer the medication.
Are there any potential side effects of Humira?
Common side effects of Humira may include injection site reactions, headache, upper respiratory infections, and rash. However, more serious side effects, such as infections or allergic reactions, can occur. It's essential to discuss potential side effects with your healthcare provider.
Can Humira be used during pregnancy or while breastfeeding?
The use of Humira during pregnancy and breastfeeding should be discussed with a healthcare provider. It's important to weigh the potential benefits against the risks, as the safety of Humira during these periods is not fully understood.
Is Humira safe for long-term use?
Humira may be prescribed for both short-term and long-term use, depending on the condition being treated. It is essential to follow your healthcare provider's guidance and undergo regular check-ups to monitor your response to the medication.
Can I drink alcohol while taking Humira?
Moderate alcohol consumption is generally considered safe while taking Humira. However, it's advisable to consult with your healthcare provider regarding alcohol consumption, as excessive alcohol intake can impact your overall health and well-being.
Where can I obtain Humira?
Humira is available by prescription only. To obtain Humira, you'll need to consult with a healthcare provider, such as a rheumatologist or gastroenterologist, who can evaluate your condition and determine if Humira is an appropriate treatment option.
Can Humira be used in combination with other medications?
Humira may be used in combination with other medications as part of a treatment plan. However, the specific combination of medications should be discussed with your healthcare provider to ensure safety and effectiveness.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 2593
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