Description
Glumetza (metformin extended release)
If you have type 2 diabetes mellitus, your doctor may have prescribed Glumetza. In people with type 2 diabetes mellitus, their bodies are less sensitive to the insulin made by their pancreas. Insulin is responsible for moving glucose into cells and providing them with energy. When insulin isn't working, the cells don't get the energy they need. Also, extra glucose in the blood damages blood vessels.
Glumetza works by making cells more sensitive to the insulin already there.
Fact Table |
Formula |
C4H11N5 |
License |
US FDA, EU EMA |
Bioavailability |
50–60% |
Legal status |
Rx-only |
Chemical Name |
Metformin |
Elimination half-life |
4–8.7 hours |
Dosage (Strength) |
500mg, 1000mg |
Pregnancy |
No Known Risk |
Brands |
Glucophage, Glumetza |
Protein binding |
Minimal |
PubChem CID |
4091 |
MedlinePlus |
a696005 |
ChEBI |
6801 |
ATC code |
A10BA02 |
DrugBank |
DB00331 |
KEGG |
D04966 |
Routes of administration |
By mouth |
Directions
The usual dosage is 500-2000 mg per day. Dosages can be divided once or twice a day.
Take Glumetza with food to lessen the side effects.
Ingredients
The active ingredient in Glumetza is metformin.
Interactions
The most common drug-drug interactions may include:
- Abemaciclib
- Alcohol
- Alpha-Lipoic Acid
- Androgens
- Beta-Blockers
- Bortezomib
- Carbonic Anhydrase Inhibitors
- Cephalexin
- Cimetidine
- Dalfampridine
- Direct Acting Antiviral Agents
- Dofetilide
- Dolutegravir
- Erdafitinib
- Etilefrine
- Fexinidazole
- Fludeoxyglucose F 18
- Gilteritinib
- Glycopyrrolate
- Guanethidine
- Guar Gum
- Hyperglycemia-Associated Agents
- Hypoglycemia-Associated Agents
- Iodinated Contrast Agents
- LamoTRIgine
- Maitake
- MATE1/2-K Inhibitors
- Monoamine Oxidase Inhibitors
- Nonsteroidal Anti-Inflammatory Agents
- Ombitasvir, Paritaprevir, and Ritonavir
- Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir
- Ondansetron
- Pacritinib
- Patiromer
- Pegvisomant
- Prothionamide
- Quinolones
- Ranolazine
- Risdiplam
- Ritodrine
- Salicylates
- Selective Serotonin Reuptake Inhibitors
- Tafenoquine
- Thiazide and Thiazide-Like Diuretics
- Topiramate
- Verapamil
- Vitamin K Antagonists
Cautions
Glumetza may need to be paused during surgery.
Extended-release metformin may remain intact and visible in the stool.
Tell your doctor if you have a history of kidney or liver problems.
Side Effects
If you are experiencing any of the following, it may be a side effect of metformin:
- Abdominal distension
- Abdominal distress
- Abdominal pain
- Abnormal stools
- Asthenia
- Chest discomfort
- Chills
- Diaphoresis
- Diarrhea
- Dizziness
- Dyspepsia
- Dyspnea
- Encephalopathy
- Fixed drug eruption
- Flatulence
- Flu-like symptoms
- Flushing
- Headache
- Heartburn
- Hemolytic anemia
- Hepatic injury
- Hypoglycemia
- Lactic acidosis
- Lichen planus
- Myalgia
- Nail disease
- Nausea and vomiting
- Palpitations
- Upper respiratory tract infection
- Vitamin B12 deficiency
References
Glumetza [package insert]. Menlo Park, CA: Depomed, Inc; 2009.
Frequently Asked Questions about Glumetza (Metformin Extended Release)
What is Glumetza used for?
Glumetza is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It's sometimes used with insulin or other medications.
How should Glumetza be taken?
Swallow the extended-release tablet whole. Do not crush, break, or chew it. Inform your doctor if you have trouble swallowing the tablets whole.
What is the drug class of Glumetza?
Glumetza belongs to the drug class Biguanide, and it's a form of Metformin Extended Release.
What are some common brand names for Metformin Extended Release?
Glumetza, Glucophage XR, and Fortamet are common brand names for Metformin Extended Release.
What should I do if I have an allergic reaction to Glumetza?
If you have an allergic reaction to Glumetza, discontinue use and seek medical attention.
Is Glumetza suitable for treating type 1 diabetes?
No, Glumetza is not for treating type 1 diabetes.
What are the forms of Glumetza available?
Glumetza is available in the form of tablets, including extended-release tablets, and an extended-release suspension.
What is the generic name for Glumetza?
The generic name for Glumetza is Metformin Hydrochloride.
What are the contraindications for Glumetza?
Do not use Glumetza if you've had an allergic reaction to Metformin. It's important to keep all medicine out of the reach of children.
Where should Glumetza be stored?
Keep Glumetza out of the reach of children, and store it in a safe place to prevent misuse.
About Dr. Conor Sheehy (Page Author)
Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 11509