What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Genvoya (Cobicistat/Elvitegravir/Emtricitabine/Tenofovir)
Prescription Required
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Product Details
Description
Genvoya consists of four drugs-elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide-to treat HIV-infection in adults and pediatric patients who weight at least 25 kg:
- And have not received any antiretroviral treatment, or
- Are replacing the current antiretroviral treatment and meet certain criteria
Genvoya may not be right for everyone. Talk to your doctor about the best treatment option for you.
Fact Table
Formula
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License
US FDA
Bioavailability
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Legal status
Rx-Only
Chemical Name
Cobicistat/Elvitegravir/Emtricitabine/Tenofovir
Elimination half-life
70.95 hours
Dosage (Strength)
150mg/150mg/200mg/10mg
Pregnancy
Consult Doctor
Brands
Genvoya
Protein binding
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PubChem CID
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MedlinePlus
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ChEBI
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ATC code
J05AR09
DrugBank
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KEGG
D10756
Routes of administration
By Mouth
Directions
You should take Genvoya as prescribed by your doctor and relay any questions or concerns to your doctor or pharmacist.
Patients generally take one tablet by mouth once daily with food.
Ingredients
Each Genvoya tablet contains 150 mg of elvitegravir (HIV-1 integrase strand transfer inhibitor), 150 mg of cobicistat (CYP3A inhibitor), 200 mg of emtricitabine (HIV-1 nucleoside analog reverse transcriptase inhibitor), and 10 mg of tenofovir alafenamide (HIV-1 nucleoside analog reverse transcriptase inhibitor).
Inactive ingredients include croscarmellose sodium, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, silicon dioxide, and sodium lauryl sulfate. The tablets are coated with FD and C Blue No. 2/indigo carmine aluminum lake, iron oxide yellow, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.
Contraindications
Genvoya should not be taken with certain drugs, including those that are:
- highly dependent on CYP3A for clearance from the body and are associated with serious reactions at high levels in the body
- those that are strong CYP3A inducers, which can decrease the effects of Genvoya
Ask your doctor if you are unsure whether or not you take these medications.
Cautions
FDA Boxed Warning: Severe acute worsening of hepatitis B have occurred in patients who are coinfected with HIV-1 and HBV and have stopped taking products containing emtricitabine and/or tenofovir disoproxil fumarate and can occur upon stopping Genvoya. Liver function should be closely monitored and treatment for hepatitis B initiated if needed.
- Before you begin treatment with Genvoya, you should tell your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your medical history and health problems
- Your pregnancy or breastfeeding status
- Kidney problems can occur with the use of Genvoya. The doctor should monitor the patient's kidney function before and during treatment with Genvoya.
- Immune system problems can occur with the use of Genvoya.
- Lactic acidosis and severe liver enlargement with fat in the liver can occur with Genvoya treatment.
Side Effects
The most common side effect associated with Genvoya is nausea. However, this is not the only side effect that can occur with Genvoya.
Contact your doctor right away if you develop side effects that bother you or won't go away.
Reference:
- Genvoya (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) tablets, for oral use. Foster City, CA: Gilead Sciences, Inc.; 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13699
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