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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Gengraf (Cyclosporine Modified)
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Generic Equivalent - Gengraf (Cyclosporine Modified)
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Product Details
Description
Gengraf is an immune suppressant used for the prevention of organ transplant rejection. It is also used in certain immunological diseases like psoriasis and rheumatoid arthritis.
Fact Table
Formula
C62H111N11O12
License
US FDA, EU EMA
Bioavailability
variable
Legal status
Rx-only
Chemical Name
Ciclosporin
Elimination half-life
variable (about 24 hours)
Dosage (Strength)
25mg, 5omg
Pregnancy
No Known Risk
Brands
Gengraf
Protein binding
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PubChem CID
5284373
MedlinePlus
a682116
ChEBI
8435
ATC code
a601207
DrugBank
DB00091
KEGG
D00184
Routes of administration
By mouth
Directions
The dosage of Gengraf is carefully determined based on blood levels. Never change your dosage without talking with your healthcare team before changing your dosage.
Ingredients
The active ingredient is cyclosporine.
Interactions
Tell your doctor before starting any of the following:
- Abrocitinib
- Aliskiren
- Asunaprevir
- Atorvastatin
- Baricitinib
- BCG Products
- Bilastine
- Bosentan
- Cladribine
- Dengue Tetravalent Vaccine
- Deucravacitinib
- Disulfiram
- DOXOrubicin
- Dronedarone
- Elagolix
- Elagolix, Estradiol, and Norethindrone
- Elbasvir and Grazoprevir
- Eplerenone
- Erdafitinib
- Fexinidazole
- Filgotinib
- Foscarnet
- Fusidic Acid
- Grapefruit Juice
- Lasmiditan
- Lercanidipine
- Lovastatin
- Methotrimeprazine
- Mifamurtide
- MiFEPRIStone
- Natalizumab
- Ornidazole
- Pacritinib
- PAZOPanib
- Pimecrolimus
- Pimozide
- Pitavastatin
- Poliovirus Vaccine
- Potassium-Sparing Diuretics
- Red Yeast Rice
- Revefenacin
- Rubella- or Varicella-Containing Live Vaccines
- Ruxolitinib
- Secnidazole
- Simeprevir
- Simvastatin
- Sirolimus
- Tacrolimus
- Talimogene Laherparepvec
- Taurursodiol
- Tertomotide
- Tofacitinib
- Topotecan
- Treosulfan
- Typhoid Vaccine
- Upadacitinib
- VinCRIStine
- Voxilaprevir
- Yellow Fever Vaccine
Cautions
Never switch between Gengraf and other forms of cyclosporine without talking with your doctor.
Speak extensively with your pharmacist and doctor about precautions relevant to you.
Side Effects
Side effects may include:
- Abdominal distension
- Abdominal distress
- Abdominal pain
- Abnormal breath sounds
- Abnormal erythrocytes
- Abnormal heart sounds
- Abscess
- Acne vulgaris
- Acute myocardial infarction
- Anemia
- Angioedema
- Anorexia
- Anxiety
- Aphthous stomatitis
- Arthralgia
- Arthropathy
- Asthenia
- Bacterial infection
- Basal cell carcinoma of the skin
- Bleeding tendency disorder
- Bone fracture
- Breast fibroadenomas
- Bronchospasm
- Bursitis
- Candidiasis
- Carcinoma
- Cardiac arrhythmia
- Cardiac failure
- Cataract
- Cellulitis
- Chest pain
- Confusion
- Conjunctivitis
- Constipation
- Cough
- Cytomegalovirus disease
- Deafness
- Decreased libido
- Depression
- Dermatitis
- Diabetes mellitus
- Diaphoresis
- Diarrhea
- Dislocation
- Disorder of hemostatic components of blood
- Dizziness
- Drowsiness
- Dyschromia
- Dysgeusia
- Dyspepsia
- Dysphagia
- Dyspnea
- Eczema
- Edema
- Emotional lability
- Enanthema
- Enlargement of salivary glands
- Epistaxis
- Eructation
- Esophagitis
- Eye pain
- Female genital tract disease
- Fever
- Flatulence
- Flu-like symptoms
- Flushing
- Folliculitis
- Fungal infection
- Gastric ulcer
- Gastritis
- Gastroenteritis
- Gingival hemorrhage
- Gingival hyperplasia
- Gingivitis
- Glossitis
- Goiter
- Gynecomastia
- Headache
- Hearing loss
- Hematuria
- Hepatotoxicity
- Herpes simplex infection
- Herpes zoster infection
- Hiccups
- Hirsutism
- Hot flash
- Hyperbilirubinemia
- Hyperglycemia
- Hyperkalemia
- Hyperkeratosis
- Hypersensitivity reaction
- Hypertension
- Hypertrichosis
- Hyperuricemia
- Hypoesthesia
- Hypoglycemia
- Hypomagnesemia
- Increased appetite
- Increased blood urea nitrogen
- Increased libido
- Increased nonprotein nitrogen
- Increased serum cholesterol
- Increased serum creatinine
- Increased serum triglycerides
- Infection
- Insomnia
- Lack of concentration
- Lethargy
- Leukopenia
- Leukorrhea
- Localized fungal infection
- Lower limb cramp
- Lymphadenopathy
- Malaise
- Malignant lymphoma
- Malignant neoplasm of skin
- Mastalgia
- Menstrual disease
- Migraine
- Muscle spasm
- Myalgia
- Nail disease (brittle fingernails)
- Nausea
- Nausea and vomiting
- Nephrotoxicity
- Nervousness
- Neuropathy
- Night sweats
- Nocturia
- Pain
- Pancreatitis
- Paranoid ideation
- Paresthesia
- Peptic ulcer
- Peripheral ischemia
- Pharyngitis
- Pneumonia
- Polyuria
- Pruritus
- Psychiatric disturbance
- Purpuric disease
- Pyelonephritis
- Qualitative disorder of platelet function
- Rectal hemorrhage
- Respiratory tract infection
- Rhinitis
- Rigors
- Seizure
- Septicemia
- Sinusitis
- Skin infection
- Squamous cell carcinoma of the skin
- Stiffness
- Synovial cyst
- Tendinopathy
- Thrombocytopenia
- Tingling sensation
- Tinnitus
- Tongue disease
- Tonsillitis
- Tremor
- Trichorrhexis
- Upper gastrointestinal hemorrhage
- Upper respiratory tract infection
- Urinary frequency
- Urinary incontinence
- Urinary tract infection
- Urinary urgency
- Urine abnormality
- Urticaria
- Uterine hemorrhage
- Vertigo
- Vestibular disturbance
- Viral infection
- Viral infection
- Visual disturbance
- Vomiting
- Weight gain
- Weight loss
- Wound infection
- Xeroderma
- Xerostomia
References
Gengraf [package insert]. North Chicago, IL: AbbVie Inc; 2021.
Frequently Asked Questions about Gengraf (Cyclosporine Modified)
What is Gengraf (Cyclosporine Modified) used for?
Gengraf is used to prevent organ rejection after a kidney, liver, or heart transplant. It's also used to treat severe cases of rheumatoid arthritis and psoriasis.
How should Gengraf be taken?
Gengraf should be taken as prescribed by your doctor, usually in two divided doses. Ensure to follow all instructions closely and read all information provided to you.
What precautions should be taken while on Gengraf?
Due to increased chances of infection, it's important to wash hands often and avoid people with infections, colds, or flu. It's also crucial to follow dosing instructions to avoid nephrotoxicity and hepatotoxicity.
What are some common side effects of Gengraf?
Common side effects include headache, stomach pain, diarrhea, upset stomach, hair growth, pimples (acne), dizziness, flushing, signs of a common cold, joint pain, and leg cramps.
What should I do in case of an overdose?
In case of an overdose, contact your poison control center or get medical care right away. Be ready to provide information on what was taken, how much, and when it happened.
How should Gengraf be stored?
Store Gengraf in the original container at room temperature, in a dry place away from the bathroom. Keep it out of reach of children and pets.
Is Gengraf a flexible dosing medication?
Yes, Gengraf provides flexible and dependable dosing options, allowing for tailored treatment as per your doctor's instructions.
Are there any contraindications for Gengraf?
Gengraf is contraindicated in patients with a hypersensitivity to cyclosporine or any ingredients of the formulation.
What is modified cyclosporine?
Modified cyclosporine is a specific formulation of cyclosporine designed for better absorption and efficacy in preventing organ rejection and treating certain autoimmune conditions.
Can Gengraf be substituted with other medications?
It's essential to follow your doctor's prescription. If "Do Not Substitute" or "Dispense as Written" is indicated on your prescription, ensure you receive Gengraf as prescribed to get the intended treatment.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10537
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