What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Fragmin (Dalteparin Sodium)
Prescription Required
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Product Details
Description
Fragmin is an anticoagulant medication belonging to the class of low-molecular-weight heparins (LMWH). It is primarily prescribed to prevent and treat conditions related to abnormal blood clotting like pulmonary embolism (PE), deep vein thrombosis (DVT), and atrial fibrillation (AFib).
Fragmin works by inhibiting certain clotting factors, preventing the formation of blood clots.
Fact Table
Formula
C26H40N2O36S5 (average for the repeating disaccharide unit)
License
US FDA, EMA
Bioavailability
87% (subcutaneous)
Legal status
Prescription only (Rx)
Chemical Name
Low molecular weight heparin (LMWH)
Elimination half-life
2-4 hours (subcutaneous)
Dosage (Strength)
2500 IU, 5000 IU, 7500 IU, 10,000 IU, 12,500 IU, 15,000 IU, 18,000 IU prefilled syringes
Pregnancy
Consult a doctor; generally considered safe
Brands
Fragmin
Protein binding
~80%
PubChem CID
772
MedlinePlus
a602008
ChEBI
CHEBI:7506
ATC code
B01AB04
DrugBank
DB06779
KEGG
D07957
Routes of administration
Subcutaneous
Directions
The Fragmin dosage is based on weight. Take it exactly as prescribed by your doctor.
Ingredients
The active ingredient in Fragmin is dalteparin sodium.
Interactions
Common drug-drug interactions may include:
- Abciximab
- Aceclofenac
- Acemetacin
- Acenocoumarol
- Alipogene Tiparvovec
- Alteplase, Recombinant
- Amtolmetin Guacil
- Anagrelide
- Anistreplase
- Antithrombin, Recombinant
- Apixaban
- Argatroban
- Aspirin
- Bemiparin
- Betrixaban
- Bivalirudin
- Bromfenac
- Bufexamac
- Caplacizumab-yhdp
- Celecoxib
- Choline Salicylate
- Citalopram
- Clonixin
- Clopidogrel
- Collagenase, Clostridium histolyticum
- Curcumin
- Dabigatran Etexilate
- Danaparoid
- Desvenlafaxine
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyridamole
- Dipyrone
- Drotrecogin Alfa
- Droxicam
- Edoxaban
- Enoxaparin
- Eptifibatide
- Escitalopram
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Ibrutinib
- Ibuprofen
- Ibuprofen Lysine
- Iloprost
- Indomethacin
- Inotersen
- Ketoprofen
- Ketorolac
- Lepirudin
- Levomilnacipran
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Milnacipran
- Morniflumate
- Nabumetone
- Nadroparin
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Nintedanib
- Omadacycline
- Orlistat
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Paroxetine
- Pentosan Polysulfate Sodium
- Phenindione
- Phenprocoumon
- Phenylbutazone
- Piketoprofen
- Piracetam
- Piroxicam
- Prasugrel
- Proglumetacin
- Propionic Acid
- Propyphenazone
- Proquazone
- Reteplase, Recombinant
- Rivaroxaban
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sarecycline
- Sertraline
- Sodium Salicylate
- Streptokinase
- Sulfinpyrazone
- Sulindac
- Tenecteplase
- Tenoxicam
- Tiaprofenic Acid
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolfenamic Acid
- Tolmetin
- Trazodone
- Treprostinil
- Turmeric
- Urokinase
- Valdecoxib
- Venlafaxine
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
Cautions
Patients using Fragmin should use caution, especially if they have a history of bleeding disorders or certain medical conditions. Regular monitoring of blood cell levels may be necessary during Fragmin therapy.
Side Effects
Common adverse reactions may include:
- Bleeding from nose
- Contusion
- Extradural intracranial hematoma
- Hematoma, Injection site
- Hematoma, Spinal
- Hemorrhage, Major
- Hemorrhagic cerebral infarction
- Increased liver function test
- Intracranial hemorrhage
- Intrauterine
- Irritation symptom, Local
- Injection site bruising
- Injection site pain
- Non-allergic anaphylaxis
- Paralysis
- Subdural hemorrhage
- Thrombocytopenia
References
Fragmin [package insert]. New York, NY: Pfizer; May 2019.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11483
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