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  Description

  Floxin, known by the generic name Ofloxacin, is a fluoroquinolone antibiotic used to treat bacterial infections in the body. It fights bacteria by interfering with their DNA replication process, effectively stopping their growth and spread. Clinicians prescribe Floxin to treat various infections, such as bronchitis, pneumonia, chlamydia, gonorrhea, skin infections, urinary tract infections, and prostatitis.

  F act Table
  Formula	C18H20FN3O4
  License	US FDA (1990)
  Bioavailability	98% (oral)
  Legal status	Prescription only (?)
  Chemical Name	(±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
  Elimination half-life	9 hours
  Dosage (Strength)	200 mg, 300 mg, 400 mg tablets; 0.3% ophthalmic solution
  Pregnancy	Consult a doctor (Category C)
  Brands	Floxin, Ocuflox
  Protein binding	32%
  PubChem CID	4583
  MedlinePlus	a688010
  ChEBI	CHEBI:7731
  ATC code	J01MA01
  DrugBank	DB01165
  KEGG	D00315
  Routes of administration	Oral, Ophthalmic, Intravenous (IV)

  Directions

  Floxin comes in different forms, including oral tablets and ear drops. The medication should be taken as prescribed for a healthcare provider. The usual dosage and dosage form for bacterial infections varies depending on the severity and type of infection. For example, the oral tablet is usually taken twice daily, and it’s best taken on an empty stomach, one hour before or two hours after meals. Always consult a healthcare provider for the appropriate dosage.

  Ingredients

  The active ingredient in Floxin is Ofloxacin. The medication may also contain inactive ingredients, such as hydroxypropyl cellulose, hypromellose, and magnesium stearate.

  Contraindications

  Floxin should not be taken if you have a hypersensitivity or allergy to Ofloxacin or other fluoroquinolones, such as Ciprofloxacin.

  Cautions

  • Speak with a healthcare provider about the following before taking Floxin:
  • Any medications you are currently taking
  • If you are pregnant or breastfeeding
  • Any allergies you may have
  • Any other medical conditions you have
  • Floxin can increase the risk of tendon problems, such as tendinitis or even tendon rupture, which might require surgery. This risk is higher in people over 60, those on steroid medication, and patients with kidney, heart, or lung transplants.
  • Floxin isn't recommended for treating infections in the urethra, vagina, cervix, rectum, or anus due to its potent nature and the sensitivity of these areas.
  • Your doctor will check your liver function with blood tests before and during treatment because Floxin can affect your liver.
  • Look out for new or worsening lung symptoms like trouble breathing, as Floxin can cause lung issues. Your treatment might need to be adjusted if this happens.
  • Don't start Floxin if your blood pressure isn't controlled. Your blood pressure will be monitored closely once you begin treatment.
  • Floxin can affect your heart's rhythm, especially if you're at risk for heart rhythm issues. Your doctor will keep a close watch on this.
  • Minimize or avoid exposure to sunlight or UV light, as Floxin can make your skin more sensitive to the sun.
  • If you have a condition like myasthenia gravis that causes muscle weakness, Floxin might make it worse. It's usually advised to avoid this medication in such cases.
  • Floxin can cause effects like seizures, tremors, or confusion. It's used cautiously in patients with conditions that predispose them to seizures.
  • Serious allergic reactions can happen, sometimes after the first dose. If you experience symptoms like hives, difficulty breathing, or swelling, stop Floxin and seek medical help immediately.

  Side Effects

  Floxin antibiotic side effects include nausea, insomnia, headaches, dizziness, diarrhea, vomiting, rash, itching, and various genital irritations. Despite the majority of these side effects being mild to moderate, they can greatly impact daily activities and overall well-being.

  Floxin carries a risk of serious adverse effects, especially tendinitis and tendon rupture, which are more likely to occur in patients over 60, those on corticosteroids, and patients with kidney, heart, or lung transplants. It may worsen muscle weakness in individuals with myasthenia gravis and should be avoided in patients with this condition. The drug is also associated with central nervous system effects, including seizures and toxic psychosis, and may cause severe hypersensitivity reactions, nerve pain, and Clostridium difficile-associated diarrhea (CDAD). Patients experiencing symptoms of serious side effects should discontinue the medication immediately and seek medical attention.

  References:

  1. Floxin (Ofloxacin) Product Monograph. Raritan, NJ: Ortho-McNeil-JanssenPharmaceuticals; 2011.
  2. Floxin (Ofloxacin) Product Monograph. Montvale, NJ: Daiichi Pharmaceutical Corporation; 2005.

  
  
  

  

  About Dr. Gerardo Sison (Page Author)

  
  Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....

  
  

  IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

  Product Code : 1533

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