What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Flolan (Epoprostenol)
Prescription Required
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Product Details
Description
Flolan is a prescription medication used primarily to treat pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the lungs' arteries, which can lead to shortness of breath, dizziness, and heart failure.
Epoprostenol works by relaxing the blood vessels in the lungs, reducing the workload on the heart, and improving blood flow. This action helps alleviate the symptoms of PAH and enhances the patient's quality of life.
Fact Table
Formula
C20H32O5
License
US FDA, EMA
Bioavailability
N/A (administered intravenously)
Legal status
Prescription only (?)
Chemical Name
(5Z,9a,11a,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid
Elimination half-life
2-3 minutes
Dosage (Strength)
0.5 mg and 1.5 mg powder for injection
Pregnancy
Consult a doctor
Brands
Flolan, Veletri
Protein binding
81%
PubChem CID
5280723
MedlinePlus
a601128
ChEBI
CHEBI:31748
ATC code
B01AC09
DrugBank
DB01240
KEGG
D00094
Routes of administration
Intravenous
Directions
Flolan is administered via continuous intravenous infusion using a portable infusion pump. The dosage and infusion rate are determined by a healthcare provider based on the patient's condition, response to treatment, and other factors.
Before starting Flolan, you must receive proper training in administration from a healthcare professional.
Ingredients
The active ingredient in Flolan is epoprostenol.
Interactions
The most common drug-drug interactions with this drug include:
- Abrocitinib
- Aceclofenac
- Acemetacin
- Amtolmetin Guacil
- Apixaban
- Argatroban
- Betrixaban
- Bivalirudin
- Bromfenac
- Bufexamac
- Caplacizumab-yhdp
- Celecoxib
- Choline Salicylate
- Citalopram
- Clonixin
- Clopidogrel
- Dabigatran Etexilate
- Danaparoid
- Desirudin
- Desvenlafaxine
- Dexibuprofen
- Dexketoprofen
- Diclofenac
- Diflunisal
- Dipyrone
- Droxicam
- Duloxetine
- Edoxaban
- Escitalopram
- Etodolac
- Etofenamate
- Etoricoxib
- Felbinac
- Fenoprofen
- Fepradinol
- Feprazone
- Floctafenine
- Flufenamic Acid
- Fluoxetine
- Flurbiprofen
- Fluvoxamine
- Fondaparinux
- Heparin
- Ibuprofen
- Indomethacin
- Ketoprofen
- Ketorolac
- Lepirudin
- Levoketoconazole
- Levomilnacipran
- Lornoxicam
- Loxoprofen
- Lumiracoxib
- Meclofenamate
- Mefenamic Acid
- Meloxicam
- Methotrexate
- Milnacipran
- Morniflumate
- Nabumetone
- Naproxen
- Nepafenac
- Niflumic Acid
- Nimesulide
- Nimesulide Beta Cyclodextrin
- Oxaprozin
- Oxyphenbutazone
- Parecoxib
- Paroxetine
- Phenindione
- Phenprocoumon
- Phenylbutazone
- Piketoprofen
- Piroxicam
- Proglumetacin
- Propyphenazone
- Proquazone
- Protein C
- Rivaroxaban
- Rofecoxib
- Salicylic Acid
- Salsalate
- Sertraline
- Sodium Salicylate
- Sulindac
- Tenoxicam
- Tiaprofenic Acid
- Tolfenamic Acid
- Tolmetin
- Valdecoxib
- Venlafaxine
- Vilazodone
- Vortioxetine
- Warfarin
Cautions
Tell your doctor if you have a history of heart disease, bleeding disorders, or liver and kidney issues before using this medication.
Flolan can increase the risk of bleeding, so avoiding activities that may cause injury is important.
Pregnant or breastfeeding women should consult their healthcare provider before starting Flolan, as its safety in these populations has not been fully established.
Side Effects
Some common side effects are:
- Abdominal pain
- Anxiety
- Arthralgia
- Bloodstream infection
- Bradyarrhythmia
- Chest pain
- Diarrhea
- Dizziness
- Feeling nervous
- Flushing
- Headache
- Hemorrhage
- Hypersplenism
- Hypotension
- Influenza-like illness
- Jaw pain
- Loss of appetite
- Musculoskeletal pain
- Nausea and vomiting
- Sepsis
- Splenomegaly
- Tachycardia
References
Flolan [package insert]. Research Triangle Park, NC: GlaxoSmithKline; January 2008.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14614
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