What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Evamist (Estradiol)
Prescription Required
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Product Details
Description
Evamist is a prescription medication used to alleviate symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness. These symptoms arise due to the natural decline in estrogen levels as women age. Evamist contains estradiol, a form of estrogen hormone, which helps restore hormone balance and relieve menopausal symptoms.
Fact Table
Formula
C18H24O2
License
US FDA
Bioavailability
1-10% (oral); 30-50% (transdermal)
Legal status
Prescription only (?)
Chemical Name
Estra-1,3,5(10)-triene-3,17ß-diol
Elimination half-life
~1-2 hours
Dosage (Strength)
1.53 mg/spray (transdermal spray)
Pregnancy
Contraindicated
Brands
Evamist, Estrace, Climara, Estraderm
Protein binding
98%
PubChem CID
5757
MedlinePlus
a682922
ChEBI
CHEBI:16469
ATC code
G03CA03
DrugBank
DB00783
KEGG
D00105
Routes of administration
Transdermal
Directions
Evamist is a transdermal spray. It is applied once daily to the inner forearm, between the elbow and wrist. The spray is quick-drying and should dry completely before covering the area with clothing.
Follow the healthcare provider's instructions regarding the dosage and application method to ensure optimal effectiveness and minimize potential side effects.
Ingredients
The active ingredient in Evamist is estradiol.
Interactions
Common drug-drug interactions may include:
- Abametapir
- Amifampridine
- Amoxicillin
- Ampicillin
- Amprenavir
- Apalutamide
- Aprepitant
- Armodafinil
- Artemether
- Bacampicillin
- Belzutifan
- Betamethasone
- Bexarotene
- Bosentan
- Bupropion
- Carbamazepine
- Carbenicillin
- Cefaclor
- Cefadroxil
- Cefdinir
- Cefditoren
- Cefixime
- Cefpodoxime
- Cefprozil
- Ceftazidime
- Ceftibuten
- Cefuroxime
- Cenobamate
- Ceritinib
- Clarithromycin
- Clobazam
- Cloxacillin
- Colesevelam
- Conivaptan
- Cosyntropin
- Cyclacillin
- Cyclosporine
- Dabrafenib
- Darunavir
- Dexamethasone
- Dicloxacillin
- Donepezil
- Doxycycline
- Efavirenz
- Elafibranor
- Elagolix
- Elvitegravir
- Enasidenib
- Encorafenib
- Enzalutamide
- Eslicarbazepine Acetate
- Etravirine
- Fedratinib
- Fexinidazole
- Fezolinetant
- Fosamprenavir
- Fosaprepitant
- Fosnetupitant
- Fosphenytoin
- Griseofulvin
- Guar Gum
- Isotretinoin
- Itraconazole
- Ivosidenib
- Lesinurad
- Lixisenatide
- Lorlatinib
- Lumacaftor
- Mavacamten
- Meropenem
- Minocycline
- Mitapivat
- Mitotane
- Mobocertinib
- Modafinil
- Mycophenolate Mofetil
- Mycophenolic Acid
- Nafcillin
- Nelfinavir
- Netupitant
- Nevirapine
- Octreotide
- Oxacillin
- Oxcarbazepine
- Oxytetracycline
- Penicillin G
- Penicillin G Procaine
- Penicillin V
- Phenobarbital
- Phenylbutazone
- Phenytoin
- Pitolisant
- Pixantrone
- Prednisolone
- Prednisone
- Primidone
- Repotrectinib
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Secobarbital
- Somatrogon-ghla
- St John's Wort
- Sugammadex
- Sultamicillin
- Tazemetostat
- Telaprevir
- Tetracycline
- Theophylline
- Ticarcillin
- Tigecycline
- Tirzepatide
- Topiramate
- Tovorafenib
- Tranexamic Acid
- Ulipristal
- Valproic Acid
Cautions
Tell your doctor about any history of breast cancer, uterine cancer, blood clots, liver disease, heart disease, or unusual vaginal bleeding.
Women who are pregnant or breastfeeding should not use Evamist.
Side Effects
Common adverse reactions may include:
- Abdominal bloating
- Abdominal pain
- Application site irritation
- Breast tenderness
- Chloasma
- Disorder of menstruation
- Edema
- Headache
- Hirsutism
- Loss of scalp hair
- Persistent erythema of skin
- Pain
- Pain of breast
- Pruritus
- Swelling of breast
- Upper respiratory infection
- Vaginal discomfort
- Weight increased
- Withdrawal bleeding
References
Evamist [package insert]. City, ST: Pharma; April 2008.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12205
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