What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Eucrisa (Crisaborole)
Prescription Required
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Product Details
Description
Your dermatologist or primary care provider may prescribe Eucrisa (crisaborole), a topical prescription medication designed to treat mild to moderate atopic dermatitis in pediatric and adult patients.
Atopic dermatitis is also referred to as eczema. Common symptoms may include itching, inflamed skin, redness, dry or scaly skin, blisters or oozing lesions, thickening skin, crusting, hyperpigmentation, papules, and sleep disturbances.
Belonging to the non-steroidal phosphodiesterase 4 (PDE-4) inhibitors class, the active ingredient increases cyclic adenosine monophosphate (cAMP) levels. This action reduces the immune response and subsequent inflammation, offering relief from symptoms associated with eczema.
Fact Table
Formula
C14H10BNO3
License
US FDA
Bioavailability
Low systemic absorption (topical use)
Legal status
Prescription only (Rx)
Chemical Name
(4-[(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy]benzyl alcohol)
Elimination half-life
~2 hours (metabolite)
Dosage (Strength)
2% topical ointment
Pregnancy
Consult a doctor
Brands
Eucrisa
Protein binding
97%
PubChem CID
16721649
MedlinePlus
a617040
ChEBI
CHEBI:82720
ATC code
D11AH04
DrugBank
DB04984
KEGG
D09730
Routes of administration
Topical
Directions
Apply a thin layer of Eucrisa to the affected area(s) twice daily.
Do not use this product for longer than prescribed by your doctor.
Eucrisa is intended for external use only and should not come into contact with the eyes, ears, nose, vagina, or other mucous membranes.
Following each application, thorough handwashing is recommended, and caution should be exercised to avoid contact with sensitive areas.
Ingredients
The active ingredient in Eucrisa is crisaborole. Additionally, the formulation includes the following inactive ingredients:
- Butylated hydroxytoluene
- Diglycerides
- Edetate calcium disodium
- Monoglycerides
- Paraffin
- Propylene glycol
- White petrolatum
Tell your doctor and other healthcare professionals if you have any history of allergic reactions to the above ingredients.
Interactions
There are no significant drug-drug interactions between Eucrisa and other medications.
Cautions
People prescribed Eucrisa should exercise caution and inform their healthcare provider of any pre-existing medical conditions, especially those related to skin infections or sensitivities.
Take Eucrisa exactly as your doctor prescribes, and do not change the dosage without consulting your physician.
Additionally, individuals with allergies to Eucrisa or its inactive ingredients should refrain from using the drug. Hypersensitivity reactions at the application site may occur, including redness, swelling, itching, hives, and difficulty breathing.
Those with a history of kidney problems should inform their doctor, as Eucrisa is primarily metabolized by the kidneys.
Side Effects
Common side effects of this drug can include:
- Application site pain
- Hypersensitivity reaction
References
Eucrisa [package insert]. New York, NY: Pfizer; March 2020.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14572
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