What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Entresto (Sacubitril/Valsartan)
Also Known as Vymada
Generic Equivalent - Entresto (Sacubitril/Valsartan)
Prescription Required
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Product Details
Description
Entresto Medication Indications
ENTRESTO is a prescription medicine used to reduce the risk of death and hospitalization in people with certain types of long-lasting (chronic) heart failure. ENTRESTO is usually used with other heart failure therapies, in place of an ACE inhibitor or other ARB therapy.
Fact Table
Formula
C96H120N12Na6O21
License
EU EMA
Bioavailability
60%
Legal status
US: RX Only
Chemical Name
Sacubitril / Valsartan
Elimination half-life
1.4-11 hours
Dosage (Strength)
24/25mg (56 or 168 tablets), 49/51mg (56 or 168 tablets), 97/103mg (56 or 168 tablets)
Pregnancy
Consult a doctor
Brands
Entresto
Protein binding
97%
PubChem CID
71449007
MedlinePlus
a682462
ChEBI
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ATC code
C09DX04
DrugBank
DB09292, DB00177
KEGG
D10226
Routes of administration
By mouth (tablets)
Directions
The recommended starting dose of Entresto is one tablet of 49 mg/51 mg twice daily, except in certain situations. The dose should be doubled at 2-4 weeks to the target dose of one tablet of 97 mg/103 mg twice daily, as tolerated by the patient. Entresto may be administered with or without food. The tablets must be swallowed with a glass of water.
Ingredients
Each film-coated tablet contains sacubitril and valsartan (as sacubitril valsartan sodium salt complex) as active ingredients.
Cautions
Do not take ENTRESTO if you: 1)are allergic to sacubitril or valsartan or any of the ingredients in ENTRESTO 2)have had an allergic reaction including swelling of your face, lips, tongue, throat (angioedema) or trouble breathing while taking a type of medicine called an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) 3)take an ACE inhibitor medicine. Do not take ENTRESTO for at least 36 hours before or after you take an ACE inhibitor medicine. Talk with your doctor or pharmacist before taking ENTRESTO if you are not sure if you take an ACE inhibitor medicine have diabetes and take a medicine that contains aliskiren
Side Effects
ENTRESTO may cause serious side effects including: angioedema that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO. People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema low blood pressure (hypotension). Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue kidney problems increased amount of potassium in your blood The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.
Frequently Asked Questions about Entresto
What is Entresto used for?
Entresto is a prescription medicine used to treat adults with long-lasting (chronic) heart failure. It helps reduce the risk of death and hospitalization. It works better when the heart cannot pump a normal amount of blood to the body.
What drugs should not be taken with Entresto?
It’s crucial to watch for potential interactions to stay safe. Avoid combining it with ACE inhibitors, ARBs like losartan, or aliskiren due to increased risks of side effects. Additionally, be cautious with medications that raise potassium levels, NSAIDs like ibuprofen, and lithium when using Entresto, as they can lead to complications and require close monitoring.
Does Entresto lower blood pressure?
Entresto combines valsartan, which relaxes blood vessels, and sacubitril, which increases beneficial peptides. Together, they lower blood pressure by promoting vasodilation and reducing fluid retention. However, individual responses may vary, so it's essential to follow healthcare provider guidance.
What are the most common side effects of Entresto?
The most common side effects of Entresto include low blood pressure, high potassium, cough, dizziness, and kidney problems.
Do Entresto side effects go away?
Most common side effects of Entresto, such as low blood pressure, dizziness, cough, and other temporary side effects, should resolve within a day of stopping the medication. Extremely low blood pressure or extremely high potassium levels may require supportive medical care but are usually corrected in a few hours.
How does Entresto work?
Entresto is an angiotensin receptor-neprilysin inhibitor. It helps relax blood vessels and reduces the strain on the heart.
How long does it take for Entresto to work?
Entresto typically starts to show its effects within a few weeks of consistent use. However, individual responses may vary.
What happens if you suddenly stop taking Entresto?
Abruptly stopping Entresto can worsen heart failure symptoms. Always follow your doctor’s instructions.
What happens if you take a double dose of Entresto?
Taking a double dose of Entresto can increase the risk of side effects. Contact your doctor if this occurs.
Can Entresto be taken once a day?
Yes, Entresto is typically taken twice daily, but consult your doctor for specific dosing instructions.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13174
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