Enbrel (Etanercept)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Prescription Required
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Product Details
Description
Enbrel (etanercept) subcutaneous injection is used to treat adults who have rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.
Enbrel is also used to treat pediatric patients who are at least 2 years of age with polyarticular juvenile idiopathic arthritis and juvenile psoriatic arthritis and pediatric patients who are at least 4 years of age with plaque psoriasis.
Enbrel is available in single-dose, prefilled syringes containing 25 mg/0.5 mL or 50 mg/mL. It is also available in a single-dose, prefilled SureClick® autoinjector containing 50 mg/mL.
Fact Table
Formula
C2224H3475N621O698S36
License
US FDA, EMA
Bioavailability
58-76% (subcutaneous)
Legal status
Prescription only (Rx)
Chemical Name
Etanercept
Elimination half-life
70-132 hours
Dosage (Strength)
25 mg, 50 mg prefilled syringes
Pregnancy
Consult a doctor
Brands
Enbrel
Protein binding
Not applicable (biologic)
PubChem CID
119496382
MedlinePlus
a602013
ChEBI
CHEBI:35608
ATC code
L04AB01
DrugBank
DB00005
KEGG
D02691
Routes of administration
Subcutaneous (SC)
Directions
Use Enbrel as directed by your doctor. Your doctor will determine an appropriate dose and treatment duration for you depending on your medical condition.
A healthcare provider will teach you or a caregiver how to properly store, prepare, administer, and discard Enbrel. Enbrel should be injected underneath the skin in the thigh, abdomen, or upper arm.
For further instructions for use, refer to the medication guide that comes with your prescription. If you have any questions or concerns, reach out to your doctor or pharmacist.
Ingredients
The active ingredient in Enbrel is etanercept.
Inactive ingredients include L-arginine hydrochloride, sodium chloride, and sucrose.
Contraindications
Patients with sepsis should not receive Enbrel injection.
Cautions
- Enbrel contains the following FDA Boxed Warning:
- The risk of serious infections that require hospitalization or cause death, including tuberculosis (TB), bacterial sepsis, invasive fungal infections, and other opportunistic infections, is increased.
- Enbrel should be stopped if a patient develops a serious infection or sepsis while receiving Enbrel therapy.
- A latent test for TB should be performed. TB treatment should be started before starting Enbrel therapy if the test is positive.
- All patients should be monitored for TB while they are receiving Enbrel, even if the first latent TB test result is negative.
- Before you begin treatment with Enbrel, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history, including
- Your pregnancy or breastfeeding status
- Enbrel is associated with the following warnings and precautions:
- Demyelinating disease that develops or gets worse
- Lymphoma
- Congestive heart failure that develops or gets worse
- Low blood cell and platelet counts
- Serious allergic reactions, including anaphylaxis
- Lupus-like syndrome or autoimmune liver inflammation
Side Effects
Infections and reactions at the injection site are common Enbrel side effects; however, other side effects may also occur. Immediately inform your doctor of any side effects that bother you or won’t go away.
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Reference
Enbrel. Thousand Oaks, CA: Immunex Corporation; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11728
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