What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Dovato
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Product Details
Description
Dovato (dolutegravir/lamivudine) is a combination drug product used to treat Human Immunodeficiency Virus (HIV). It works by disrupting the virus's ability to replicate. You can buy Dovato as a 50mg/300mg tablet. Store your Dovato tablets at room temperature.
Directions
- You can take Dovato without regard to meals.
- Dovato can be affected by foods and products that contain calcium, magnesium, iron, and aluminum. Take Dovato at least two hours before, or six hours after consuming any of the listed products.
- If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, then skip the dose you missed and continue with your regular schedule.
- Do not take two doses of Dovato at the same time.
- The usual dose for Dovato is one tablet once per day.
Ingredients
- The active ingredients of Dovato are dolutegravir and lamivudine. Find a complete list of inactive ingredients in the package insert.
Cautions
- Dovato has a black box warning that reads: PATIENTS CO-INFECTED WITH HEPATITIS B VIRUS (HBV) AND HUMAN IMMUNODEFICIENCY VIRUS (HIV-1): EMERGENCE OF LAMIVUDINE-RESISTANT HBV AND EXACERBATIONS OF HBV
- Do not take Dovato if you are allergic to any of its ingredients.
- Dovato can interact with other drugs. Talk to your doctor about any other medications you are taking before starting Dovato.
- Do not take Dovato if you are currently using dofetilide. The reaction is potentially life-threatening.
- If you have underlying liver disease, you could be a higher risk of severe adverse effects. Discuss your risk with your physician.
- If you are pregnant or planning to become pregnant, discuss the risks of Dovato with your physician. Dovato could cause harm to a fetus in the first trimester of pregnancy.
- Dovato can cause a condition called Immune Reconstitution Syndrome. Discuss the risk with your physician.
Side Effects
Dovato side effects include:
- Severe Effects:
- Lactic acidosis
- Hepatitis Exacerbation
- Hepatotoxicity
- Injury of the liver
- Immune Reconstitution Syndrome
- Hypersensitivity Reaction
- Common Effects:
- Nausea
- Diarrhea
- Headache
- Insomnia
- Fatigue
Other Considerations
- Compare the Dovato price at Canada Pharmacy to your local drug store.
References:
- Immune reconstitution inflammatory syndrome. (2019). Retrieved March 22, 2020
- Dovato. (n.d.). Retrieved March 21, 2020, from
- DailyMed - DOVATO- DOLUTEGRAVIR sodium and lamivudine TABLET, film coated. (2019). Retrieved March 21, 2020
Fact Table
Formula
C20H19F2N3O5, C8H11N3O3S
License
AU, EU EMA, US FDA
Bioavailability
Dolutegravir: -, Lamivudine: 86%
Legal status
RX Only
Chemical Name
Dolutegravir/Lamivudine
Elimination half-life
Dolutegravir: ~14 hours, Lamivudine: 5 – 7 hours
Dosage (Strength)
50/300mg (30 tablets)
Pregnancy
Consult a doctor
Brands
Dovato
Protein binding
Dolutegravir: great than equal to 98.9%, Lamivudine: less than 36%
PubChem CID
Dolutegravir: DB00709, Lamivudine: 60825
MedlinePlus
Dolutegravir: a696011, Lamivudine: a696011
ChEBI
Dolutegravir: 76010, Lamivudine: 63577
ATC code
Dolutegravir: J05AJ03, J05AR13, J05AR21, Lamivudine: J05AF05
DrugBank
Dolutegravir: DB08930, Lamivudine: DB00709
KEGG
Dolutegravir: D10066, Lamivudine: D00353
Routes of administration
By mouth
Frequently Asked Questions about Dovato
What is Dovato?
Dovato is a prescription medicine that is used to treat HIV-1 infection in adults who have not received antiretroviral treatment before and who have no known resistance to the individual components of the medicine.
How does Dovato work?
Dovato contains two active ingredients: dolutegravir and lamivudine. These ingredients work together to reduce the amount of HIV in the body and keep the virus under control.
How is Dovato taken?
Dovato is taken as a single tablet once daily. It can be taken with or without food.
Are there any side effects associated with Dovato?
Like all medicines, Dovato can cause side effects. Common side effects include headache, diarrhea, and nausea. It's important to consult with a healthcare professional about potential side effects.
Can I take Dovato with other medications?
Some medications can interact with Dovato, affecting how it works. Always inform your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What should I do if I miss a dose?
If you miss a dose of Dovato, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and take the next one at the regular time. Do not take two doses at the same time.
Is Dovato a cure for HIV?
No, Dovato is not a cure for HIV. It is a treatment that helps control the virus and prevent it from progressing to AIDS.
Can I drink alcohol while taking Dovato?
There are no known direct interactions between Dovato and alcohol. However, excessive alcohol consumption can weaken the immune system and may interfere with HIV treatment. It's best to discuss alcohol consumption with your healthcare provider.
Do I need to take Dovato for the rest of my life?
HIV is a chronic condition, and currently, there is no cure. This means that ongoing treatment is necessary to manage the virus. It's essential to discuss your treatment plan with your healthcare provider.
Where can I get more information about Dovato?
For more detailed information about Dovato, consult the patient information leaflet provided with the medication or speak with your healthcare provider.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13261
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