What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Cuvposa (Glycopyrrolate)
Prescription Required
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Product Details
Description
Your doctor may prescribe Cuvposa to manage severe drooling in children aged 3 to 16 with certain neurologic disorders, such as cerebral palsy. Excessive drooling can cause discomfort and skin irritation, along with other complications.
The active ingredient, glycopyrrolate, is an anticholinergic drug that reduces saliva production by blocking acetylcholine receptors. Blocking acetylcholine receptors helps control drooling and improves quality of life.
Fact Table
Formula
C19H28BrNO3
License
US FDA
Bioavailability
~30%
Legal status
Prescription only (Rx)
Chemical Name
(RS)-3-(2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidinium bromide
Elimination half-life
0.6–1.2 hours
Dosage (Strength)
1 mg/5 mL oral solution
Pregnancy
Consult a doctor
Brands
Cuvposa, Robinul, Seebri, Lonhala
Protein binding
38% (plasma proteins)
PubChem CID
3493
MedlinePlus
a682620
ChEBI
CHEBI:5546
ATC code
A03AB02, R03BB06
DrugBank
DB00986
KEGG
D00554
Routes of administration
Oral, Inhalation
Directions
Administer Cuvposa three times daily, ideally 1 hour before or 2 hours after meals, as instructed by your healthcare provider. The dosage depends on the child’s weight and response.
Ingredients
The active ingredient in Cuvposa is glycopyrrolate.
Interactions
Common drug-drug interactions may include:
- Aclidinium
- Amantadine
- Amifampridine
- Amitriptyline
- Amoxapine
- Atropine
- Belladonna
- Benzhydrocodone
- Benztropine
- Biperiden
- Brompheniramine
- Buprenorphine
- Bupropion
- Carbinoxamine
- Carisoprodol
- Chlorpheniramine
- Chlorpromazine
- Clemastine
- Clidinium
- Clomipramine
- Clozapine
- Codeine
- Cyclobenzaprine
- Cyclopentolate
- Cyproheptadine
- Darifenacin
- Desipramine
- Dicyclomine
- Dihydrocodeine
- Dimenhydrinate
- Diphenhydramine
- Donepezil
- Doxepin
- Fentanyl
- Fesoterodine
- Flavoxate
- Fluphenazine
- Glucagon
- Glycopyrronium Tosylate
- Homatropine
- Hydrocodone
- Hydromorphone
- Hydroxyzine
- Hyoscyamine
- Imipramine
- Ipratropium
- LetibotulinumtoxinA-wlbg
- Loxapine
- Meclizine
- Mepenzolate
- Meperidine
- Methacholine
- Methadone
- Morphine
- Morphine Sulfate Liposome
- Nortriptyline
- Olanzapine
- Oliceridine
- Orphenadrine
- Oxitropium Bromide
- Oxybutynin
- Oxycodone
- Oxymorphone
- Paroxetine
- Perphenazine
- Pimozide
- Pipenzolate Bromide
- Pirenzepine
- Potassium Chloride
- Prochlorperazine
- Procyclidine
- Promethazine
- Propantheline
- Propiverine
- Protriptyline
- Quetiapine
- Revefenacin
- Scopolamine
- Secretin Human
- Sofpironium
- Solifenacin
- Stramonium
- Sufentanil
- Tapentadol
- Terodiline
- Thioridazine
- Thiothixene
- Tiotropium
- Tizanidine
- Tolterodine
- Tramadol
- Trifluoperazine
- Trihexyphenidyl
- Trimipramine
- Tropicamide
- Trospium
- Umeclidinium
Cautions
Cuvposa can cause drowsiness or blurred vision. Avoid activities that require alertness, such as riding a bicycle, until you know how this medication affects your child.
Ensure your child stays hydrated, especially in hot weather or during physical activity, as glycopyrrolate can decrease sweating, increasing the risk of heatstroke.
Side Effects
Common side effects of Cuvposa may include:
- Angle-closure glaucoma
- Angioedema
- Atrial fibrillation
- Bradyarrhythmia
- Cardiac arrest
- Cardiac dysrhythmia
- Constipation
- Dyspnea
- Flushing
- Heat exhaustion
- Hypersensitivity reaction
- Malignant hyperthermia
- Nasal congestion
- Nasopharyngitis
- Nystagmus
- Paradoxical bronchospasm
- Pseudo-obstruction of intestine
- Respiratory arrest
- Seizure
- Somnolence
- Tachycardia
- Upper respiratory infection
- Urinary tract infectious disease
- Ventricular fibrillation
- Vomiting
- Xerostomia
References
Cuvposa [package insert]. Raleigh, NC: Merz; 2016.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14921
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