What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Cotellic (Cobimetinib)
Prescription Required
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Product Details
Description
Cotellic (cobimetinib) is a prescription medication used to treat adults with unresectable or metastatic melanoma or histiocytic neoplasms.
Cotellic is available in 20 mg oral tablets.
Fact Table
Formula
C21H21F3IN3O2
License
US FDA, EMA
Bioavailability
46%
Legal status
Prescription only (Rx)
Chemical Name
N-[3-[3-(Cyclopropylcarbamoyl)-4-fluorophenyl]-1-methyl-1H-pyrazol-5-yl]-4-iodo-2-(trifluoromethyl)benzamide
Elimination half-life
43.6 hours
Dosage (Strength)
20 mg tablets
Pregnancy
Contraindicated
Brands
Cotellic
Protein binding
95%
PubChem CID
25141685
MedlinePlus
a615019
ChEBI
CHEBI:90942
ATC code
L01XE38
DrugBank
DB05710
KEGG
D10310
Routes of administration
Oral
Directions
Take Cotellic exactly as prescribed by your doctor, as he or she will determine an appropriate Cotellic dosage for you.
Keep Cotellic tablets stored at room temperature that’s less than 30oC (86oF) and away from children’s reach.
To learn more about Cotellic use, refer to the medication guide that comes with your Cotellic prescription.
If you have any questions or concerns, do not hesitate to reach out to your doctor or pharmacist.
Ingredients
The active ingredient in Cotellic is cobimetinib.
Inactive ingredients include microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, titanium dioxide, polyethylene glycol 3350, and talc.
Contraindications
According to the most recent Prescribing Information, there are no contraindications to taking Cotellic.
Cautions
- Before you begin Cotellic treatment, talk to your doctor about:
- All the prescription and over-the-counter medications you take
- Your allergies
- Your current health problems and past medical history
- Your pregnancy or breastfeeding status
- Cotellic is associated with the following warnings and precautions:
- The development of new cancers
- Major bleeding
- Heart muscle disease
- Severe skin rashes
- Eye problems, including retinopathy and retinal vein occlusion
- Liver problems
- Breakdown of muscle tissue, resulting in the release of substances in the blood that can cause kidney damage
- Severe photosensitivity; sun exposure should be avoided
- Harm to an unborn baby; females who are capable of reproducing should use effective contraceptive methods during Cotellic treatment and for 2 weeks after taking the final dose
- Breastfeeding is not recommended
Side Effects
Unresectable or metastatic melanoma: Diarrhea, photosensitivity, nausea, fever, vomiting, abnormal labs (increased GGT, CPK, and liver enzymes and decreased phosphorus, sodium, and lymphocytes) are the most common Cotellic side effects; however, other side effects may also occur.
Histiocytic neoplasms: Acne, skin conditions, diarrhea, infection, fatigue, nausea, swelling, dry skin, skin rash, itching, indigestion, vomiting, shortness of breath, urinary tract infections, anemia, and abnormal labs (decreased sodium, potassium, calcium, lymphocytes, and leukocytes and increased CPK, creatinine, and liver enzymes) are the most common Cotellic side effects; however, other side effects may also occur.
Immediately inform your doctor of any side effects that bother you or won’t go away.
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References
- Cotellic. South San Francisco, CA: Genentech USA, Inc.; 2023.
- Rhabdomyolysis. Cleveland Clinic; Last reviewed February 24, 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14610
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