What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Chantix (Varenicline)
Also Known as Champix
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Product Details
Description
Chantix (Varenicline) is a medication prescribed as an aid during smoking cessation. Chantix is a short-term medication that is taken over several months to help dampen cravings and response to nicotine.
Chantix binds to nicotinic acetylcholine receptors, which are the same targets as nicotine in tobacco. When Chantix binds to these receptors, it activates them but at a much lower level than nicotine. It also blocks nicotine from binding and activating these receptors, preventing the euphoria and addiction response caused by nicotine in the brain.
Directions
Take Chantix exactly as directed on the packaging. Chantix is typically first dispensed as a starter pack that contains both 0.5 mg tablets and 1 mg tablets.
After the starting pack, the typical maintenance dose of Chantix is 1 mg twice daily for 11 weeks. However, the dose may vary so take exactly as instructed by your physician.
Ingredients
The active ingredient is Chantix is varenicline.
Cautions
After approval by the FDA, patients have reported the following neuropsychiatric side effects:
- Agitation
- Anxiety
- Changes in mood
- Completed Suicide
- Delusions
- Hallucinations
- Homicidal Ideation
- Hostility
- Panic
- Paranoia
- Psychosis
- Suicidal Ideation
- Suicide attempt
Most patients will not experience any of the above side effects, but if you do, please tell your physician or pharmacist immediately. You may need to stop taking Chantix and try a different medication for tobacco cessation.Some patients taking Chantix have reported swelling of the skin, particularly in the face, mouth, limps, and throat. Stop taking Chantix if you experience swelling after taking it.
Some people have reported serious skin reactions like Stevens-Johnson Syndrome and Erythema Multiform after starting Chantix . Tell your physician if you have a history of these conditions.
Fact Table
Formula
C13H13N3
License
EU EMA
Bioavailability
High and unaffected by food consumption or time of day
Legal status
RX Only
Chemical Name
Varenicline
Elimination half-life
24 hours
Dosage (Strength)
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Pregnancy
Consult a doctor
Brands
Chantix
Protein binding
less than 20%
PubChem CID
5310966
MedlinePlus
a606024
ChEBI
84500
ATC code
N07BA03
DrugBank
DB01273
KEGG
D08669
Routes of administration
By mouth
Side Effects
The most common Chantix side effects reported in the original clinical trials were:
- Abnormal Dreams
- Headache
- Insomnia
- Nausea
These side effects were also the most reported reasons for stopping Chantix. Stopping nicotine may also cause the listed side effects, so it is unclear how much nicotine withdrawal contributes to the adverse effects of Chantix.References
- Chantix [package insert]. New York, NY: Pfizer; 2009.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 9423
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