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Cerdelga (Eliglustat)

What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

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  • Product Details

    Description

    Cerdelga (eliglustat) is a medication prescribed to treat adults long-term with Gaucher disease type 1.

    Cerdelga comes in 84 mg capsules for oral administration.

    Fact Table

    Formula

    C23H36N2O4

    License

    US FDA, EMA

    Bioavailability

    6.5% (oral)

    Legal status

    Prescription only

    Chemical Name

    N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-((2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl)ethyl]octanamide

    Elimination half-life

    6 to 8 hours (CYP2D6 extensive metabolizers)

    Dosage (Strength)

    84 mg capsules

    Pregnancy

    Consult a doctor

    Brands

    Cerdelga

    Protein binding

    76% to 83%

    PubChem CID

    23727837

    MedlinePlus

    a614024

    ChEBI

    CHEBI:85173

    ATC code

    A16AX10

    DrugBank

    DB11579

    KEGG

    D10089

    Routes of administration

    Oral

    Directions

    Take Cerdelga exactly as prescribed by your doctor.

    Your doctor will decide on appropriate Cerdelga dosing for you based on your CYP2D6 genotype as determined by an FDA-cleared test.

    You should not consume grapefruit or grapefruit juice while taking Cerdelga. Swallow the capsules whole; they should not be crushed, dissolved, or opened.

    Keep Cerdelga stored between 20°C and 25°C (68°F and 77°F) and out of children’s reach.

    For further instructions for use, you may refer to the medication guide that comes with your Cerdelga prescription.

    Tell your doctor or pharmacist about any questions or concerns you have.

    Ingredients

    The active ingredient in Cerdelga is eliglustat.

    Inactive ingredients include candurin silver fine, FD&C blue 2, gelatin, glyceryl behenate, hypromellose, lactose monohydrate, microcrystalline cellulose, and yellow iron oxide.

    Contraindications

    Contraindications depend on your CYP2D6 genotype:

    Extensive metabolizers (EMs)

    • Taking a strong or moderate CYP2D6 inhibitor with a strong or moderate CYP3A inhibitor
    • Moderate or severe liver impairment
    • Mild liver impairment taking a strong or moderate CYP2D6 inhibitor

    Immediate metabolizers (IMs)

    • Taking a strong or moderate CYP2D6 inhibitor with a strong or moderate CYP3A inhibitor
    • Taking a strong CYP3A inhibitor
    • Any degree of liver impairment

    Poor metabolizers (PMs)

    • Taking a strong CYP3A inhibitor
    • Any degree of liver impairment

    Cautions

    • Before you start taking Cerdelga, inform your doctor of:
      • All the prescription and over-the-counter medications you take
      • Your allergies
      • Your current health problems and past medical history
      • Your pregnancy or breastfeeding status
    • Cerdelga is not recommended in patients who have pre-existing heart disease, long QT syndrome, and are receiving Class IA or Class III antiarrhythmics.

    Side Effects

    Fatigue, headache, nausea, diarrhea, back pain, pain in the arms and legs, and upper abdominal pain are some Cerdelga side effects; however, other side effects may also occur.

    Inform your doctor right away if you have side effects that bother you or won't go away.

    Searching for a competitive Cerdelga price? With a valid prescription, you can buy Cerdelga right here!

    Reference

    Cerdelga. Cambridge, MA: Genzyme Corporation, A Sanofi Company; 2024.



    Dr Savannah Muncy
    About Dr. Savannah Muncy (Page Author)


    Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....


    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 14892

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