What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Cequa (Cyclosporine)
Prescription Required
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Product Details
Description
Cequa is a prescription ophthalmic solution used to treat dry eye disease, which is also known as keratoconjunctivitis sicca. This condition is characterized by chronic dryness, inflammation, and discomfort in the eyes.
Cequa contains cyclosporine, an immunomodulatory agent that helps increase tear production and reduce inflammation, thereby alleviating the symptoms of dry eye disease. It particularly benefits patients who have not responded well to artificial tears or other over-the-counter treatments.
Fact Table
Formula
C62H111N11O12
License
US FDA
Bioavailability
~30% (oral)
Legal status
Prescription only (?)
Chemical Name
Cyclo[[(E)-(2S,3R,4R,6E)-3-hydroxy-4-methoxy-2-methyl-6-octenoyl]-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-valyl-N-methyl-L-leucyl-N-methyl-L-alanyl-L-alanyl-]]
Elimination half-life
8.4 hours
Dosage (Strength)
0.09% ophthalmic solution
Pregnancy
Consult a doctor
Brands
Cequa, Restasis, Sandimmune, Neoral
Protein binding
90-98%
PubChem CID
5284373
MedlinePlus
a601207
ChEBI
CHEBI:4031
ATC code
S01XA18
DrugBank
DB00091
KEGG
D00185
Routes of administration
Ophthalmic, Oral, Intravenous
Directions
The usual dosage is one drop in each affected eye twice daily, approximately 12 hours apart.
Do not touch the tip of the dropper bottle to the eye because it can contaminate the medication.
For the best results, it is important to follow your healthcare provider’s instructions and use Cequa consistently.
Ingredients
The active ingredient in Cequa is cyclosporine.
Interactions
Common drug-drug interactions with this medication can include:
- Bosentan
- Colchicine
- Dronedarone
- Elagolix
- Eliglustat
- Ezetimibe
- Grazoprevir
- Lercanidipine
- Levoketoconazole
- Mifepristone
- Pitavastatin
- Simvastatin
- Sitaxsentan
Cautions
Before starting Cequa, tell your doctor if you have any history of eye infections, herpes keratitis, or any other eye conditions.
Do not use Cequa if you are allergic to cyclosporine or any other ingredients in the solution.
Do not instill Cequa while you have contact lenses in place. If you wear contact lenses, remove them before applying Cequa and wait at least 15 minutes before reinserting them.
Use caution to avoid contamination by not touching the dropper tip to the eye, hands, or another surface.
Side Effects
The most common side effects of this drug may include:
- Application site reaction
- Blepharitis
- Burning sensation in the eye
- Conjunctival hyperemia
- Disease caused by Polyomavirus
- Drug-induced gingival hyperplasia
- Encephalopathy
- Eye irritation
- Headache
- Hemolytic uremic syndrome
- Hepatotoxicity
- Hirsutism
- Hyperkalemia
- Hypomagnesemia
- Hypertension
- Infectious disease
- Nephrotoxicity
- Pain in eye
- Progressive multifocal leukoencephalopathy
- Seizure
- Tremor
References
Cequa [package insert]. Cranbury, NJ: Sun Pharmaceutical Industries; Aug 2018.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14637
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