Description
Cataflam® (diclofenac potassium immediate-release tablets) is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of mild to moderate pain and the treatment of primary dysmenorrhea. It is also used to alleviate the signs and symptoms of osteoarthritis and rheumatoid arthritis. Each tablet contains 50 mg of diclofenac potassium, which functions by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis and thereby decreasing inflammation and pain.
| Fact Table |
| Formula | C14H10Cl2NO2 |
| License | US FDA |
| Bioavailability | 50–60% (oral) |
| Legal status | Rx-only |
| Chemical Name | Diclofenac potassium |
| Elimination half-life | 1–2 hours |
| Dosage (Strength) | 25 mg, 50 mg, 100 mg tablets |
| Pregnancy | Avoid in 3rd trimester; consult doctor (Category C/D) |
| Brands | Cataflam, Voltaren (other salt forms), Cambia |
| Protein binding | >99% |
| PubChem CID | 3033 |
| MedlinePlus | a689002 |
| ChEBI | 4719 |
| ATC code | M01AB05 |
| DrugBank | DB00586 |
| KEGG | D07813 |
| Routes of administration | Oral |
Directions
For the treatment of pain or primary dysmenorrhea, the recommended dosage is 50 mg three times daily. Some patients may benefit from an initial dose of 100 mg, followed by 50 mg doses. For osteoarthritis, the recommended dosage is 100-150 mg per day, divided into 50 mg two or three times daily. For rheumatoid arthritis, the recommended dosage is 150-200 mg per day, divided into 50 mg three or four times daily. Dosage should be adjusted to the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Ingredients
- Active Ingredient: Diclofenac potassium 50 mg per tablet.
- Inactive Ingredients: Calcium phosphate, colloidal silicon dioxide, iron oxide, magnesium stearate, microcrystalline cellulose, povidone, starch, sucrose, talc, and titanium dioxide.
Contraindications
Cataflam is contraindicated in patients with:
- Known hypersensitivity to diclofenac or any component of the product.
- History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
- In the setting of coronary artery bypass graft (CABG) surgery.
Cautions
- Cardiovascular Risk: NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may increase with duration of use.
- Gastrointestinal Risk: NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
- Hepatic Effects: Elevations of liver enzymes and, rarely, severe hepatic reactions can occur. Monitor liver function during prolonged therapy.
- Renal Effects: Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Use with caution in patients with impaired renal function.
- Pregnancy: Avoid use in late pregnancy as it may cause premature closure of the ductus arteriosus.
Side Effects
Common adverse reactions may include:
- Gastrointestinal discomfort (e.g., nausea, dyspepsia, abdominal pain).
Serious but less common side effects include:
- Gastrointestinal bleeding or ulceration.
- Myocardial infarction or stroke.
- Serious skin reactions (e.g., Stevens-Johnson syndrome).
IMPORTANT NOTE:
The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.
Product Code : 1469
Prescription Required
