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Buscopan (Hyoscine Butylbromide)

Brand

Buscopan (Hyoscine Butylbromide)

Strength
Qty
10mg
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  • Related Products & Conditions

  • Product Details

    Description

    Buscopan (Hyoscine Butylbromide) is an antispasmodic medication used to relieve pain and cramps in the stomach, intestines, and bladder. It works by relaxing the smooth muscles in the gastrointestinal and urinary tracts. Commonly used to treat conditions like irritable bowel syndrome (IBS), bladder spasms, and period pain, Buscopan is available in tablet form and by injection.

    Fact Table

    Formula

    C21H30NO4Br

    License

    Various national regulatory agencies (e.g., EMA, TGA)

    Bioavailability

    Low (poorly absorbed orally)

    Legal status

    OTC (varies by country)

    Chemical Name

    Hyoscine butylbromide

    Elimination half-life

    5 hours (IV)

    Dosage (Strength)

    10 mg tablets, 20 mg/mL injection

    Pregnancy

    Consult a doctor; Category B2 (AU)

    Brands

    Buscopan, Buscopan Forte, Scopolamine Butylbromide

    Protein binding

    4.4%

    PubChem CID

    5281059

    MedlinePlus

    a682143

    ChEBI

    50568

    ATC code

    A03BA03

    DrugBank

    DB00404

    KEGG

    D08180

    Routes of administration

    Oral, Intravenous, Intramuscular, Rectal

    Directions

    Buscopan is taken orally, usually as a 10 mg tablet. Adults typically start with a dosage of one to two tablets three times a day. If needed, the dosage may be adjusted by a healthcare provider. Take the tablet with water and do not crush or chew the tablet. Always follow your healthcare provider’s instructions.

    Ingredients

    Buscopan tablets contains the active ingredient Hyoscine Butylbromide. The tablets may also include several inactive ingredients, such as:

    • Calcium hydrogen phosphate
    • Dried maize starch
    • Soluble maize starch
    • Colloidal silica
    • Tartaric acid
    • Stearic/palmitic acid
    • Sucrose
    • Talc
    • Acacia
    • Titanium dioxide (E171)


    These inactive ingredients help form the tablet and aid its effectiveness.

    Contraindications

    Certain conditions make the use of this medication unsafe. Avoid taking or using this medication if any of the following apply:

    • You are allergic to hyoscine butylbromide or any other ingredients in these tablets.
    • You cannot tolerate or digest some sugars (the coating has a small amount of sucrose).
    • You have an eye condition called glaucoma.
    • You have a muscle weakness disorder known as myasthenia gravis.
    • You have or might have a blockage in your bowel.
    • Your bowel is blocked and not working properly (paralytic or obstructive ileus), causing severe belly pain, no bowel movements, and possibly nausea or vomiting.
    • Your bowel is very enlarged (megacolon).
    • You are pregnant, trying to get pregnant, or are breastfeeding.


    Taking Buscopan in these situations can lead to serious complications. Always consult a healthcare provider before starting new medications.

    Cautions

    • Before starting Buscopan, tell your doctor:
      • About any medications you are taking, especially if they include anticholinergics, antihistamines, antidepressants, or antacids.
      • If you have any medical conditions, like glaucoma, heart problems, prostate problems, or myasthenia gravis.
      • If you are pregnant or plan to become pregnant. Buscopan may not be safe for your unborn baby.
      • If you are breastfeeding or plan to breastfeed, as Buscopan can pass into breast milk and might affect your baby.
      • If you have a history of allergic reactions to Hyoscine Butylbromide or other similar medications.
    • Do not use Buscopan continuously or for extended periods without checking the cause of your abdominal pain.
    • If you're sensitive to certain medications like belladonna, you might also react to Buscopan.
    • Serious allergic reactions, including anaphylaxis, can occur, especially with injections; observe carefully after administration.
    • Buscopan can cause fast heart rate and low blood pressure, which may be risky for those with heart conditions.
    • Each sugar-coated tablet contains sucrose; not suitable for people with hereditary fructose intolerance.
    • Be cautious if you have gastrointestinal issues like reflux or obstructive diseases, as Buscopan can decrease intestinal movement and worsen these conditions.
    • Men with enlarged prostate may experience worsened urinary retention.
    • High doses or injections may cause temporary visual problems; do not drive or operate heavy machinery if affected.
    • Use with caution if you have angle-closure glaucoma, as it may increase eye pressure.
    • Limited data on the use during pregnancy and breastfeeding; best to avoid.
    • Not recommended for children.
    • Elderly may experience intensified side effects like constipation, dry mouth, and urinary retention.
    • Operating vehicles or machinery might be hazardous due to potential dizziness or vision issues after taking Buscopan.

    Side Effects

    Buscopan is used to treat stomach cramps, and while it's generally safe, it can cause some mild side effects. These include dry mouth, a faster heartbeat, blurry vision, and sometimes increased eye pressure. It might also make it hard for some people to urinate. Less often, you might feel nauseous or have diarrhea.

    Although rare, Buscopan can cause severe allergic reactions that might be life-threatening, like swelling in the face, difficulty breathing, or severe skin rashes. Some people could experience very low blood pressure or intense flushing. If you notice these or any sudden problems with your eyesight or if it becomes difficult to urinate, you should get medical help right away. These serious side effects are uncommon but may require immediate attention.

    References

    1. Buscopan (Hyoscine Butylbromide) Package Leaflet. Reggello, Italy: Istituto De Angeli S.r.l.; 2024.
    2. Buscopan (Hyoscine Butylbromide) Drug Label Information. Laval, Quebec: Sanofi-Aventis Canada Inc.; 2017.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 10077

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