What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Brukinsa (Zanubrutinib)
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Product Details
Description
Brukinsa (Zanubrutinib) is a type of medicine used to treat certain cancers. It works by blocking a protein called BTK that is important for the growth and survival of some cancer cells. This medicine is mainly used to treat mantle cell lymphoma, a cancer of the lymphatic system, and Waldenström macroglobulinemia, a type of blood cancer, among other types of cancer. Brukinsa comes in the form of capsules that you take by mouth.
Directions
Brukinsa is taken orally. The standard dosage is 160 mg twice daily or 320 mg once daily. It can be taken with or without food. Capsules should be swallowed whole with water. Do not open, break, or chew the capsules. Healthcare providers may adjust the dosage based on individual responses or any side effects experienced. Follow the dosage instructions closely and consult a healthcare provider about any concerns or questions.
Ingredients
The active ingredient in Brukinsa is Zanubrutinib.
Contraindications
There are no specific contraindications listed on the drug label. However, you should avoid taking or using this medication if you have a known hypersensitivity to Zanubrutinib or any of the medication’s ingredients.
Cautions
- Before beginning treatment with Brukinsa, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- Brukinsa can cause severe or fatal bleeding, including in the brain or gastrointestinal tract. Bleeding can occur even without using blood thinners. Watch for signs of bleeding and stop Brukinsa if there’s any brain bleeding. Consider pausing treatment before surgery to reduce the risk of bleeding.
- Brukinsa can lead to serious infections, including pneumonia, and in some cases, these infections can be fatal. Patients may also experience reactivation of hepatitis B. If you’re at high risk for infections, you might need preventive treatment. Be sure to report any signs of infection, such as fever, immediately.
- Brukinsa may cause dangerously low levels of neutrophils (a type of white blood cell), platelets, and red blood cells. Regular blood tests will be required to monitor your blood counts, and treatment may need to be adjusted. Medications or transfusions may be used to manage low counts.
- Using Brukinsa may increase the risk of developing skin cancers. It's important to protect yourself from sun exposure and schedule regular skin checks to monitor for any new signs of skin cancer.
- Some patients taking Brukinsa have experienced serious heart rhythm issues, including atrial fibrillation and flutter. If you have heart risk factors or an infection, you may be at higher risk. Watch for symptoms like palpitations, dizziness, or shortness of breath.
- Severe liver injury, including life-threatening cases, can happen while using Brukinsa. Your doctor will check your liver function regularly. If signs of liver damage appear, Brukinsa may need to be paused or stopped.
- Brukinsa can harm a developing unborn baby. Women should avoid getting pregnant while on Brukinsa and for one week after stopping. Men should avoid fathering a child during treatment and for one week after the last dose.
Side Effects
Brukinsa side effects may include a decrease in white blood cell and platelet counts, which may increase your risk of infection or bleeding. You might also experience muscle, bone, or joint pain, as well as upper respiratory tract infections. These side effects are typically manageable but should be monitored by your healthcare provider, especially if they worsen over time.
Brukinsa may lead to serious side effects, including bleeding problems that can sometimes be life-threatening. Be alert for signs of severe bleeding, such as blood in your stool, vomit, or urine, and contact your doctor immediately if you experience dizziness, confusion, or a prolonged headache. Brukinsa can also increase the risk of serious infections, heart rhythm problems, liver issues, and new cancers. If you notice symptoms like fever, irregular heartbeat, chest discomfort, or yellowing of the skin or eyes, seek medical help right away.
References
- Brukinsa (Zanubrutinib) Product Monograph. San Mateo, CA: BeiGene USA, Inc.; 2024.
- Brukinsa (Zanubrutinib) Drug Label Information. San Mateo, CA: BeiGene USA, Inc.; 2024.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14592
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