What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Braftovi (Encorafenib)
Prescription Required
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Product Details
Description
Your oncologist may prescribe Braftovi for treating specific advanced cancers, particularly unresectable or metastatic melanoma with BRAF V600E or V600K mutation. Additionally, it is prescribed for metastatic colorectal cancer featuring a BRAF V600E mutation.
Before initiating treatment, these genetic markers must be confirmed through an FDA-approved test. Braftovi operates by obstructing abnormal signals within cancer cells that contribute to uncontrolled growth.
Fact Table
Formula
C22H27ClFN7O4
License
US FDA, EMA
Bioavailability
86%
Legal status
Prescription only (?)
Chemical Name
Methyl N-{(2S)-1-[(4-{4-chloro-3-(difluoromethyl)phenyl}ureido]-2-(4-morpholinyl)ethyl}carbamate
Elimination half-life
6 hours
Dosage (Strength)
50 mg, 75 mg, 100 mg capsules
Pregnancy
Use with caution
Brands
Braftovi
Protein binding
86-89%
PubChem CID
46220502
MedlinePlus
a618013
ChEBI
134722
ATC code
L01XE45
DrugBank
DB11718
KEGG
D10709
Routes of administration
Oral
Directions
The dosage is either 300 mg or 450 mg daily, depending on what is being treated.
Ingredients
The active ingredient is encorafenib.
Interactions
The most common drug-drug interactions include:
- Abametapir
- Adagrasib
- Alfuzosin
- Amiodarone
- Amisulpride
- Amitriptyline
- Anagrelide
- Apalutamide
- Apomorphine
- Aprepitant
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Asenapine
- Astemizole
- Atazanavir
- Atorvastatin
- Azithromycin
- Bedaquiline
- Boceprevir
- Bosentan
- Buprenorphine
- Buserelin
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clothiapine
- Clozapine
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclobenzaprine
- Cyclosporine
- Dabrafenib
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Desogestrel
- Deutetrabenazine
- Dexmedetomidine
- Dienogest
- Diltiazem
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Droperidol
- Drospirenone
- Ebastine
- Efavirenz
- Elagolix
- Entrectinib
- Enzalutamide
- Eribulin
- Erythromycin
- Escitalopram
- Estradiol
- Ethinyl Estradiol
- Ethynodiol
- Etonogestrel
- Etrasimod
- Etravirine
- Famotidine
- Fedratinib
- Felbamate
- Fexinidazole
- Fingolimod
- Flecainide
- Fluoxetine
- Fluvoxamine
- Formoterol
- Foscarnet
- Fosnetupitant
- Fosphenytoin
- Fostemsavir
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Gepirone
- Gestodene
- Glasdegib
- Glyburide
- Gonadorelin
- Goserelin
- Granisetron
- Grazoprevir
- Halofantrine
- Haloperidol
- Histrelin
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Irinotecan
- Itraconazole
- Ivabradine
- Ivosidenib
- Lapatinib
- Lefamulin
- Lenvatinib
- Letermovir
- Leuprolide
- Levofloxacin
- Levonorgestrel
- Lofexidine
- Lopinavir
- Lorlatinib
- Lumacaftor
- Lumefantrine
- Macimorelin
- Mavacamten
- Medroxyprogesterone
- Mefloquine
- Mestranol
- Methadone
- Methotrexate
- Methotrimeprazine
- Metronidazole
- Mifepristone
- Mirtazapine
- Mitotane
- Mizolastine
- Mobocertinib
- Modafinil
- Moricizine
- Moxifloxacin
- Nafarelin
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant
- Nilotinib
- Nirmatrelvir
- Nomegestrol
- Norelgestromin
- Norethindrone
- Norfloxacin
- Norgestimate
- Norgestrel
- Octreotide
- Ofloxacin
- Olanzapine
- Omaveloxolone
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Pacritinib
- Paliperidone
- Panobinostat
- Papaverine
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pipamperone
- Pitavastatin
- Pitolisant
- Ponesimod
- Pravastatin
- Primidone
- Probucol
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Quizartinib
- Ranolazine
- Relugolix
- Repaglinide
- Revefenacin
- Ribociclib
- Rifabutin
- Rifampin
- Risperidone
- Ritonavir
- Rosuvastatin
- Selpercatinib
- Sertindole
- Sertraline
- Sevoflurane
- Simvastatin
- Siponimod
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- St John's Wort
- Sulfasalazine
- Sulpiride
- Sultopride
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telaprevir
- Telavancin
- Telithromycin
- Tenofovir Alafenamide
- Tetrabenazine
- Tolterodine
- Topotecan
- Toremifene
- Trazodone
- Triclabendazole
- Trimipramine
- Triptorelin
- Ubrogepant
- Ulipristal
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verapamil
- Vilanterol
- Vinflunine
- Voclosporin
- Voriconazole
- Vorinostat
- Zotepine
- Zuclopenthixol
Cautions
Ask your pharmacist or doctor about precautions that apply to you.
Side Effects
Common adverse reactions to this drug include:
- Abdominal pain
- Acneiform eruption
- ALT/SGPT level raised
- Anemia
- Arthralgia
- Basal cell carcinoma of the skin
- Bleeding from anus
- Cancer
- Cardiomyopathy
- Cough (Non-small cell lung cancer)
- Decrease in appetite
- Diarrhea
- Dyspnea (Non-small cell lung cancer)
- Fatal Intracranial hemorrhage
- Fatigue
- Gastrointestinal hemorrhage
- Hematochezia
- Hemorrhage
- Hemothorax
- Hypersensitivity reaction
- Left ventricular cardiac dysfunction
- Musculoskeletal pain (Non-small cell lung cancer)
- Nausea
- Prolonged QT interval
- Papilloma
- Rash
- Rectal hemorrhage
- Squamous cell carcinoma of the skin
- Uveitis
- Vomiting
- Visual impairment (Non-small cell lung cancer)
References
- Braftovi [package insert]. Boulder, Colorado: Array BioPharma; February 2022.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14575
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