Name: Braftovi (Encorafenib)
Brand: Braftovi (Encorafenib)
SKU: 14575
Availability: InStock

Product Details

Description

Your oncologist may prescribe Braftovi for treating specific advanced cancers, particularly unresectable or metastatic melanoma with BRAF V600E or V600K mutation. Additionally, it is prescribed for metastatic colorectal cancer featuring a BRAF V600E mutation.

Before initiating treatment, these genetic markers must be confirmed through an FDA-approved test. Braftovi operates by obstructing abnormal signals within cancer cells that contribute to uncontrolled growth.

Fact Table
Formula	C22H27ClFN7O4
License	US FDA, EMA
Bioavailability	86%
Legal status	Prescription only (?)
Chemical Name	Methyl N-{(2S)-1-[(4-{4-chloro-3-(difluoromethyl)phenyl}ureido]-2-(4-morpholinyl)ethyl}carbamate
Elimination half-life	6 hours
Dosage (Strength)	50 mg, 75 mg, 100 mg capsules
Pregnancy	Use with caution
Brands	Braftovi
Protein binding	86-89%
PubChem CID	46220502
MedlinePlus	a618013
ChEBI	134722
ATC code	L01XE45
DrugBank	DB11718
KEGG	D10709
Routes of administration	Oral

Directions

The dosage is either 300 mg or 450 mg daily, depending on what is being treated.

Ingredients

The active ingredient is encorafenib.

Interactions

The most common drug-drug interactions include:

Abametapir
Adagrasib
Alfuzosin
Amiodarone
Amisulpride
Amitriptyline
Anagrelide
Apalutamide
Apomorphine
Aprepitant
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Atazanavir
Atorvastatin
Azithromycin
Bedaquiline
Boceprevir
Bosentan
Buprenorphine
Buserelin
Carbamazepine
Cenobamate
Ceritinib
Chloroquine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clofazimine
Clomipramine
Clothiapine
Clozapine
Cobicistat
Conivaptan
Crizotinib
Cyclobenzaprine
Cyclosporine
Dabrafenib
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Desogestrel
Deutetrabenazine
Dexmedetomidine
Dienogest
Diltiazem
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Doxepin
Droperidol
Drospirenone
Ebastine
Efavirenz
Elagolix
Entrectinib
Enzalutamide
Eribulin
Erythromycin
Escitalopram
Estradiol
Ethinyl Estradiol
Ethynodiol
Etonogestrel
Etrasimod
Etravirine
Famotidine
Fedratinib
Felbamate
Fexinidazole
Fingolimod
Flecainide
Fluoxetine
Fluvoxamine
Formoterol
Foscarnet
Fosnetupitant
Fosphenytoin
Fostemsavir
Galantamine
Gatifloxacin
Gemifloxacin
Gepirone
Gestodene
Glasdegib
Glyburide
Gonadorelin
Goserelin
Granisetron
Grazoprevir
Halofantrine
Haloperidol
Histrelin
Hydroxychloroquine
Hydroxyzine
Ibutilide
Idelalisib
Iloperidone
Imatinib
Imipramine
Indinavir
Inotuzumab Ozogamicin
Irinotecan
Itraconazole
Ivabradine
Ivosidenib
Lapatinib
Lefamulin
Lenvatinib
Letermovir
Leuprolide
Levofloxacin
Levonorgestrel
Lofexidine
Lopinavir
Lorlatinib
Lumacaftor
Lumefantrine
Macimorelin
Mavacamten
Medroxyprogesterone
Mefloquine
Mestranol
Methadone
Methotrexate
Methotrimeprazine
Metronidazole
Mifepristone
Mirtazapine
Mitotane
Mizolastine
Mobocertinib
Modafinil
Moricizine
Moxifloxacin
Nafarelin
Nafcillin
Nefazodone
Nelfinavir
Netupitant
Nilotinib
Nirmatrelvir
Nomegestrol
Norelgestromin
Norethindrone
Norfloxacin
Norgestimate
Norgestrel
Octreotide
Ofloxacin
Olanzapine
Omaveloxolone
Ondansetron
Osilodrostat
Osimertinib
Oxaliplatin
Ozanimod
Pacritinib
Paliperidone
Panobinostat
Papaverine
Paroxetine
Pasireotide
Pazopanib
Pentamidine
Perphenazine
Phenobarbital
Phenytoin
Pimavanserin
Pipamperone
Pitavastatin
Pitolisant
Ponesimod
Pravastatin
Primidone
Probucol
Procainamide
Prochlorperazine
Promethazine
Propafenone
Protriptyline
Quetiapine
Quinidine
Quinine
Quizartinib
Ranolazine
Relugolix
Repaglinide
Revefenacin
Ribociclib
Rifabutin
Rifampin
Risperidone
Ritonavir
Rosuvastatin
Selpercatinib
Sertindole
Sertraline
Sevoflurane
Simvastatin
Siponimod
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
St John's Wort
Sulfasalazine
Sulpiride
Sultopride
Sunitinib
Tacrolimus
Tamoxifen
Telaprevir
Telavancin
Telithromycin
Tenofovir Alafenamide
Tetrabenazine
Tolterodine
Topotecan
Toremifene
Trazodone
Triclabendazole
Trimipramine
Triptorelin
Ubrogepant
Ulipristal
Vandetanib
Vardenafil
Vemurafenib
Venlafaxine
Verapamil
Vilanterol
Vinflunine
Voclosporin
Voriconazole
Vorinostat
Zotepine
Zuclopenthixol

Cautions

Ask your pharmacist or doctor about precautions that apply to you.

Side Effects

Common adverse reactions to this drug include:

Abdominal pain
Acneiform eruption
ALT/SGPT level raised
Anemia
Arthralgia
Basal cell carcinoma of the skin
Bleeding from anus
Cancer
Cardiomyopathy
Cough (Non-small cell lung cancer)
Decrease in appetite
Diarrhea
Dyspnea (Non-small cell lung cancer)
Fatal Intracranial hemorrhage
Fatigue
Gastrointestinal hemorrhage
Hematochezia
Hemorrhage
Hemothorax
Hypersensitivity reaction
Left ventricular cardiac dysfunction
Musculoskeletal pain (Non-small cell lung cancer)
Nausea
Prolonged QT interval
Papilloma
Rash
Rectal hemorrhage
Squamous cell carcinoma of the skin
Uveitis
Vomiting
Visual impairment (Non-small cell lung cancer)

References

Braftovi [package insert]. Boulder, Colorado: Array BioPharma; February 2022.

About Dr. Conor Sheehy (Page Author)

Dr. Sheehy (BSc Molecular Biology, PharmD) works a clinical pharmacist specializing in cardiology, oncology, and ambulatory care. He’s a board-certified pharmacotherapy specialist (BCPS), and his experience working one-on-one with patients to fine tune their medication and therapy plans for optimal results makes him a valuable subject matter expert for our pharmacy. Read More....

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

Product Code : 14575

Product Reviews

Braftovi (Encorafenib)