Description

Bimzelx, also known as Bimekizumab, is a new medication used to treat moderate to severe plaque psoriasis. It works by blocking certain proteins in the body, specifically IL-17A and IL-17F, that are involved in the inflammation related to psoriasis. This makes it the first treatment that can specifically target both of these proteins. Bimzelx is given as a self-injection, which means patients can administer it themselves at home.

Directions

Bimzelx is a medication that is given through an injection under the skin. It’s typically given as a total dose of 320 mg, which is split into two injections of 160 mg each. The usual dosage schedule is as follows:

• First 16 weeks: You will get an injection every 4 weeks.
• After 16 weeks: The injections will change to every 8 weeks.

If you weigh more than 120 kg (265 lbs), your doctor might recommend that you continue getting injections every 4 weeks even after the first 16 weeks. It's important to stick to the schedule your doctor gives you, and make sure to follow the instructions for storing and preparing the medication.

Ingredients

Bimzelx contains an active ingredient known as Bimekizumab-bkzx.

Contraindications

There are no known contraindications on the drug label. However, Bimzelx might not be the right choice if you have a known hypersensitivity to Bimekizumab or any of its components.

Cautions

• Before beginning treatment with Bimzelx, it's important to discuss the following with your healthcare provider:
• Your current health conditions
• Any allergies you may have
• All medications you are currently using
• Whether you are pregnant or breastfeeding

• Clinical trials have noted a higher occurrence of suicidal thoughts in patients on Bimzelx. If you experience mood changes or suicidal thoughts, contact your healthcare provider immediately.
• Bimzelx may raise your risk of infections, particularly respiratory and fungal infections. Do not start treatment if you have an active infection.
• Screen for tuberculosis before starting Bimzelx. Treat latent tuberculosis prior to using this medication and monitor for symptoms during treatment.
• Liver enzyme increases have been linked to Bimzelx. Liver function should be tested before and during treatment, and the medication may need to be paused if liver enzymes rise significantly.
• Avoid Bimzelx if you have active inflammatory bowel disease. Watch for and report any new or worsening symptoms of bowel inflammation.
• Complete all necessary vaccinations before starting Bimzelx, as live vaccines are not recommended during treatment. Discuss vaccination timing with your doctor.

Side Effects

Bimzelx side effects include upper respiratory infections and headaches. Patients might also experience pain, redness, or swelling at the injection site. Other common issues include fungal infections such as oral thrush, herpes simplex infections (like cold sores), and gastroenteritis. Additionally, some people may notice acne, small red bumps on the skin, or feel unusually tired.

Bimzelx can cause serious health issues, particularly affecting the liver and digestive system. Symptoms such as right-sided stomach pain, nausea, dark urine, light-colored stools, or yellowing skin or eyes require immediate contact with a healthcare provider. Those with Crohn’s disease or ulcerative colitis should monitor for worsening symptoms, as Bimzelx may trigger flare-ups or new cases of inflammatory bowel disease.

References

1. Bimzelx (Bimekizumab) Product Monograph. Smyrna, GA: UCB, Inc.; 2023.
2. Bimzelx (Bimekizumab) Drug Label Information. Smyrna, GA: UCB, Inc.; 2023.

About Dr. Gerardo Sison (Page Author)

Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....

Product Code : 13775