What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Atelvia (Risedronate) Delayed Release
Also Known as Actonel Dr
Prescription Required
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Product Details
Description
Atelvia, also known as Risedronate Sodium, is a medication used to treat osteoporosis in postmenopausal women. It works by blocking the activity of osteoclasts, the cells that break down bone, which helps to slow bone loss and can lead to an increase in bone mass. Classified as a bisphosphonate, Atelvia helps stabilize bone density and may prevent fractures. Doctors prescribe this medication to women at risk of bone loss and to ensure better bone health.
F act Table
Formula
C7H10NO7P2Na
License
US FDA
Bioavailability
~0.63% (oral, fasting)
Legal status
Prescription only (Rx)
Chemical Name
[1-hydroxy-2-(3-pyridinyl)ethylidene]bis[phosphonic acid] monosodium salt
Elimination half-life
1.5 hours (serum), up to 10 years (bone)
Dosage (Strength)
35 mg (delayed-release tablet)
Pregnancy
Consult a doctor
Brands
Atelvia, Actonel
Protein binding
~24%
PubChem CID
224004
MedlinePlus
a601114
ChEBI
3666
ATC code
M05BA07
DrugBank
DB00884
KEGG
D08456
Routes of administration
Oral
Directions
Atelvia is taken orally as a delayed-release tablet. The standard dosage involves a once-a-week tablet of 35 mg, taken first thing in the morning at least 30 minutes before any food, beverages, or other medications. Swallow the tablet whole with 6-8 ounces of plain water, remaining upright for at least 30 minutes to facilitate delivery to the stomach and reduce the chance of esophageal irritation. It's important to follow a healthcare provider's instructions closely regarding additional calcium or vitamin D supplementation that may be necessary while on Atelvia.
Ingredients
The active ingredient in Atelvia is Risedronate Sodium.
Contraindications
People with the following conditions should avoid using this medication:
- Esophageal abnormalities: Conditions that slow esophageal emptying like stricture or achalasia.
- Unable to stand or sit upright for at least 30 minutes: Staying upright helps reduce the risk of esophageal issues after taking the tablet.
- Low blood calcium (hypocalcemia): It’s necessary to correct calcium levels before starting treatment.
- Hypersensitivity: Allergic reactions to risedronate or other ingredients in Atelvia.
Cautions
- Before starting treatment with Atelvia, be sure to inform your healthcare provider about the following:
- Any medical conditions you currently have
- Any allergies
- All medications you are currently taking
- Whether you are pregnant or breastfeeding
- If you’re taking a medicine called Actonel, you shouldn’t take Atelvia. They have the same active ingredient.
- Be cautious if you have stomach problems like heartburn, swallowing issues, or ulcers. Atelvia might irritate your stomach.
- Watch out for new or worsening heartburn, pain behind your breastbone, or trouble swallowing. Stop taking Atelvia and see your doctor if these occur.
- Make sure you have enough calcium and vitamin D. You might need to take supplements if your diet doesn’t provide enough.
- There’s a risk of jaw bone problems, especially after dental work like tooth extractions. Talk to your dentist and doctor about any planned dental work.
- If you experience severe or disabling pain in your bones, joints, or muscles, stop taking Atelvia and contact your doctor.
- There’s a rare chance of unusual thigh bone fractures. If you feel any new or unusual pain in your hips, groin, or thighs, tell your doctor right away.
- Atelvia is not recommended if you have severe kidney problems.
- This medication might affect the results of certain bone-imaging tests.
Side Effects
Atelvia side effects may include diarrhea, flu-like symptoms, muscle pain, and pain in the back and joints. Some people may also experience upset stomach or abdominal pain. These side effects are generally manageable and can be typical of medications affecting bone density.
Atelvia can also cause more severe issues. Problems in the esophagus such as irritation, inflammation, or ulcers may occur, and it's crucial to take Atelvia exactly as prescribed to minimize these risks. Low calcium levels in your blood could also worsen, leading to muscle spasms, twitches, or numbness. Serious jaw bone problems (osteonecrosis), severe bone, joint, or muscle pain, and unusual thigh bone fractures are other significant risks. If you experience symptoms like chest pain, difficulty swallowing, severe pain in bones or joints, or any new thigh, hip, or groin pain, contact your doctor immediately. These conditions require prompt medical attention to prevent more serious outcomes.
References
- Atelvia (Risedronate) Product Monograph. Madison, NJ: Allergan USA, Inc.; 2020.
- Atelvia (Risedronate) Drug Label Information. Madison, NJ: Allergan USA, Inc.; 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12818
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