What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Asendin (Amoxapine)
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Product Details
Description
Your doctor may prescribe Asendin if you suffer from Major Depressive Disorder (MDD). MDD is a mood disorder that impacts daily living. Symptoms may include sleepiness, hopelessness, loss of interest, irritability, weight change, or thoughts of suicide.
Asendin works by increasing the amounts of the neurotransmitters serotonin, norepinephrine, and dopamine. These chemical signals work in the brain to produce thoughts, feelings, and moods.
Fact Table
Formula
C17H16ClN3O
License
US FDA
Bioavailability
More than 60%
Legal status
Rx-only
Chemical Name
Amoxapine
Elimination half-life
8–10 hours
Dosage (Strength)
25mg, 50mg, 100mg
Pregnancy
Consult Doctor
Brands
Asendin
Protein binding
90%
PubChem CID
2170
MedlinePlus
a682202
ChEBI
2675
ATC code
N06AA17
DrugBank
DB00543
KEGG
D00228
Routes of administration
Oral
Directions
The starting dosage of Asendin is 25-50 mg by mouth 1-3 times per day. The effective dose usually ranges from 200-300 mg divided 2-3 times per day.
The maximum recommended dosage is 400 mg per day.
Ingredients
The active ingredient in Asendin is amoxapine. Asendin is the brand name for this medication.
Interactions
Common drug-drug interactions with Asendin may include:
- Abiraterone
- Azelastine
- Bromperidol
- Bupropion
- Cinacalcet
- Dacomitinib
- Darifenacin
- Darunavir
- Dronedarone
- Duloxetine
- Fluoxetine
- Givosiran
- Glycopyrrolate
- Ipratropium
- Levosulpiride
- Linezolid
- Lorcaserin
- Methylene Blue
- Mirabegron
- Monoamine Oxidase Inhibitors
- Orphenadrine
- Paroxetine
- Perhexiline
- Potassium Chloride
- Pramlintide
- Quinidine
- Rolapitant
- Selegiline
- Terbinafine (systemic)
- Thalidomide
- Thioridazine
- Tiotropium
- Tipranavir
- Umeclidinium
Tell your healthcare team about all medications you are taking before starting Asendin.
Cautions
Do not stop taking Asendin without speaking with your doctor. Symptoms of discontinuation syndrome may include nausea, vomiting, diarrhea, dizziness, sweating, and other symptoms. You may need a slow taper to safely stop this medication.
Tell your doctor if you have any concerning mood changes while taking this medication.
Speak to your doctor or pharmacist about additional precautions that may apply to you.
Side Effects
Amoxapine side effects may include the following common ones:
- Anxiety
- Ataxia
- Blurred Vision
- Confusion
- Constipation
- Diaphoresis
- Dizziness
- Drowsiness
- Edema
- EEG pattern changes
- Excitement
- Fatigue
- Headache
- Increased appetite
- Increased serum prolactin
- Insomnia
- Nausea
- Nervousness
- Nightmares
- Palpitations
- Restlessness
- Skin rash
- Tremor
- Weakness
- Xerostomia
References
- Asendin [package insert]. Parsippany, NJ: Watson; 2014.
Frequently Asked Questions about Asendin (Amoxapine)
What is Asendin (Amoxapine)?
Asendin, or Amoxapine, is a tricyclic antidepressant used to treat symptoms of depression and related mood disorders.
How does Asendin work?
Asendin works by affecting certain chemicals in the brain, restoring the balance of neurotransmitters to alleviate depressive symptoms.
What conditions does Asendin treat?
Asendin is primarily prescribed for major depressive disorder and other mood disorders.
What are the common side effects of Asendin?
Common side effects may include drowsiness, dizziness, dry mouth, and constipation. Consult your doctor if these persist.
How long does it take for Asendin to show results?
Improvement in symptoms may take several weeks. It's essential to continue the medication as directed by your healthcare provider.
Can Asendin be taken with other medications?
Inform your doctor about all medications, including over-the-counter drugs and herbal supplements, to avoid potential interactions.
Are there any food or beverage restrictions with Asendin?
Avoid consuming grapefruit or grapefruit juice while taking Asendin, as it may interact with the medication.
Can I drink alcohol while on Asendin?
Limit alcohol intake, as it can enhance the sedative effects of Asendin and increase the risk of side effects.
Is Asendin safe during pregnancy and breastfeeding?
Consult your healthcare provider before using Asendin if you are pregnant, planning to become pregnant, or breastfeeding.
What should I do if I miss a dose of Asendin?
Take the missed dose as soon as you remember. However, if it's close to the next scheduled dose, skip the missed one and continue with the regular dosing schedule. Do not double up on doses.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 11353
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