What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Amrix (Cyclobenzaprine HCL Extended Release)
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Generic Equivalent - Amrix (Cyclobenzaprine Hydrochloride Extended-Release Capsules)
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Product Details
Description
Amrix is an extended-release muscle relaxant prescribed to relieve muscle spasms associated with musculoskeletal conditions and pain. It blocks nerve impulses (or pain sensations) sent to the brain.
Amrixis is structurally related to tricyclic antidepressants and exerts its muscle relaxant effects centrally within the nervous system.
Amrix is typically prescribed as part of a treatment plan that includes physical therapy or bedrest. Amrix provides short-term relief that allows a person to take advantage of long-term aspects of the comprehensive plan.
Fact Table
Formula
C20H21N
License
US FDA
Bioavailability
33-55%
Legal status
Prescription only (?)
Chemical Name
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
Elimination half-life
18 hours (immediate-release), up to 32 hours (extended-release)
Dosage (Strength)
15 mg, 30 mg extended-release capsules
Pregnancy
Use with caution
Brands
Amrix, Fexmid, Flexeril (immediate-release)
Protein binding
93%
PubChem CID
2895
MedlinePlus
a682514
ChEBI
CHEBI:4006
ATC code
M03BX08
DrugBank
DB00924
KEGG
D00346
Routes of administration
Oral
Directions
The usual dosage of Amrix is 15-30 mg by mouth once daily.
To maintain the extended-release properties, Amrix should be taken at the same time each day and swallowed whole, not crushed or chewed.
It is important to follow the prescribing physician's instructions carefully and avoid exceeding the recommended dosage.
Ingredients
The active ingredient in Amrix is cyclobenzaprine.
Interactions
Common drug-drug interactions with Amrix may include:
- Bepridil
- Cisapride
- Dronedarone
- Furazolidone
- Iproniazid
- Isocarboxazid
- Levoketoconazole
- Levomethadyl
- Linezolid
- Mesoridazine
- Methylene Blue
- Moclobemide
- Pargyline
- Phenelzine
- Pimozide
- Piperaquine
- Potassium Citrate
- Procarbazine
- Rasagiline
- Safinamide
- Saquinavir
- Selegiline
- Sparfloxacin
- Terfenadine
- Thioridazine
- Tranylcypromine
- Ziprasidone
Cautions
Amrix should be used with caution in patients with a history of heart disease, hyperthyroidism, or glaucoma.
Amrix may cause drowsiness, dizziness, and impaired coordination, so patients should avoid driving or operating machinery until they know how the medication affects them.
Amrix is not recommended for long-term use and should only be used for short periods (usually up to two or three weeks) unless otherwise directed by a healthcare provider.
Side Effects
The most common side effects may include:
- Abnormal liver function
- Anaphylaxis
- Bone marrow depression
- Cardiac dysrhythmia
- Cerebrovascular accident
- Cholestasis
- Constipation
- Dizziness
- Edema of the tongue
- Fatigue
- Heart block
- Hepatitis
- Indigestion
- Myocardial infarction
- Nausea
- Neuroleptic malignant syndrome
- Parotid swelling
- Paralytic ileus
- Psychotic disorder
- Serotonin syndrome
- Somnolence
- Syncope
- Thrombocytopenia
- Xerostomia
References
Amrix [package insert]. Vandalia, OH: Teva; April 2019.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 12153
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