Alhemo (Concizumab)
What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
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Product Details
Description
Alhemo, or concizumab, is a biological agent indicated to treat the hematologic disorder hemophilia B. Hemophilia B is a condition where the blood does not clot normally, and the person is more likely to have excessive bleeding. Symptoms include unexplained bleeding, blood in the urine or stool, large or deep bruises, or signs and symptoms of serious bleeds.
Alhemo works by binding to the protein TFPI. Normally, TFPI prevents the excessive formation of blood clots. By binding to this protein, Alhemo prevents TFPI from working, increases blood clotting, and reduces excessive bleeding.
Directions
Alhemo is available in the following dosage forms:
- 15 mg
- 60 mg
- 150 mg
- 300 mg
Alhemo is administered on a set schedule based on directions from your doctor. After four weeks of treatment, your doctor will measure the level of Alhemo in the blood and adjust the dose accordingly.
Ingredients
The active ingredient in Alhemo is concizumab.
Interactions
Common drug-drug interactions with Alhemo may include:
- Activated prothrombin complex concentrates (PCC)
- Recombinant FVIIa (rFVIIa)
- rFVIII
- rFVIX
Cautions
Alhemo may cause serious blood clots that can lead to permanent damage or death. Tell your doctor if you have a personal or family history of blood clots.
Ask your doctor or pharmacist to review the signs and symptoms of blood clots and monitor for them during treatment.
Alhemo should not be used in patients younger than 12 years of age.
Alhemo should not be used during pregnancy. If you may become pregnant while taking Alhemo, use a highly effective method of birth control during treatment and for seven weeks after finishing.
If you miss a dose, contact your doctor or pharmacist for instructions.
Side Effects
The most common adverse effects of this drug may include:
- Allergic reaction (hypersensitivity reaction)
- Blood clots
- Fever
- Headache
- Increase in level of blood clotting component (fibrin D dimer)
- Increase in level of blood clotting component (prothrombin fragment 1.2)
- Infections
References
Alhemo [package insert]. Mississauga, Ontario: Novo Nordisk; March 2023.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14431
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