Adtralza (Tralokinumab)

Description

Adtralza, known by its generic name Tralokinumab, is a monoclonal antibody prescribed to treat adults with moderate to severe atopic dermatitis, commonly known as eczema. It targets interleukin-13 (IL-13), a key protein involved in inflammation and symptoms associated with atopic dermatitis. Adtralza may help reduce the immune system's overactivity that causes inflammation. Doctors and healthcare providers may prescribe this medication for patients not receiving adequate relief from topical treatments. It may sometimes be used in combination with topical corticosteroids to better manage the condition.

Directions

Adtralza is administered as a subcutaneous injection, which is an injection just under the skin. The initial dose is typically 600 mg, with subsequent 300 mg doses administered every other week. Follow your healthcare provider’s instructions and make sure the skin is clean and free from any signs of infection before injecting. It’s recommended to rotate injection sites to reduce irritation.

Ingredients

Adtralza injections contain the active ingredient Tralokinumab.

Contraindications

Avoid taking or using this medication if you have a known hypersensitivity to Tralokinumab or experienced an allergic reaction to any ingredient of the Adtralza formulation.

Cautions

• Before starting on Adtralza, discuss the following with a doctor or healthcare provider:
• Allergies to medication ingredients, to avoid severe reactions.
• Current medications, including over-the-counter drugs and supplements, as they can interact with Adtralza.
• Medical history, especially infections or immune system problems, since Adtralza may affect immune responses.
• Pregnancy status or intentions, as effects on the unborn child are not well established.
• Breastfeeding plans, because it's unknown if Adtralza passes into breast milk.

• Make sure the name and batch number of Adtralza are recorded when you receive it. This is important for tracking the use of this biological medicine.
• If you have a hypersensitivity reaction after taking Adtralza, like a rash, swelling, or difficulty breathing, stop using the medication and seek medical help immediately.
• In case you develop inflammation of the eye that doesn't respond to usual treatments while on Adtralza, an eye exam may be recommended.
• Before starting Adtralza, treat any existing helminth infections. If you get a helminth infection during treatment and standard treatments don't work, you might need to pause your Adtralza therapy until the infection is resolved.
• You should avoid live vaccines while using Adtralza, as their safety with this medication hasn't been established. It's recommended to bring your vaccinations up to date with the current guidelines before starting Adtralza.
• Adtralza contains very little sodium, less than 1 mmol (23 mg) per 150 mg dose, which is almost sodium-free. This may be important if you're monitoring your sodium intake.

Side Effects

Adtralza may cause a range of side effects, though not everyone will experience them. The most common side effects include eye discomfort and symptoms of the common cold, such as body aches, chills, coughing, and ear congestion. Some people also report headaches and a stuffy or runny nose.

Certain adverse reactions to Adtralza may be more severe and require immediate attention. These could involve signs of allergic reactions like hives and swelling of the face, lips, or tongue which could potentially affect breathing. If any of these severe side effects occur, contact a healthcare provider promptly.

References:

1. Adtralza (Tralokinumab) Summary of Product Characteristics. Ballerup, Denmark: LEO Pharma; 2021.
2. Adtralza (Tralokinumab) Medicine Overview. Amsterdam, The Netherlands: European Medicines Agency; 2022.

About Dr. Gerardo Sison (Page Author)

Dr. Sison graduated with honors from the University of Florida. He began his career in pharmacy counseling patients in a community setting and later served in hospitals and clinics. He has also worked in medication therapy management services. Read More....

Product Code : 14428