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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Colcrys (Colchicine)
Also Known as Colgout
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Product Details
Description
Colcrys For Gout
Colcrys is a prescription medication generally used to treat acute flairs in patients with gout. This medication can also treat several medical conditions including recurrent and painful form of arthritis in patients with familial Mediterranean fever (FMF); and an inherited inflammatory disorder.
Acute gout can cause severe inflammation with the presence of uric acid crystals that form in bony joints. This causes severe pain, redness, and swelling of the affected joint(s). COLCRYS is useful in suppressing inflammation caused by gout.
Important: Colcrys is not an analgesic (pain killer), but it reduces pain caused by gout.
Fact Table
Formula
C22H25NO6
License
FDA approved
Bioavailability
45% (oral)
Legal status
Prescription only
Chemical Name
Colchicine
Elimination half-life
26.6 - 31.2 hours
Dosage (Strength)
0.6 mg tablets
Pregnancy advice
Use only if clearly needed and the potential benefits outweigh the risks. Consult a healthcare provider.
Brands
Colcrys, Mitigare
Protein binding
39-44%
PubChem CID
6167
MedlinePlus
a682711
ChEBI
CHEBI:27882
ATC code
M04AC01
DrugBank
DB01394
KEGG
D00570
Routes of administration
Oral, Intravenous (for acute gout only)
Directions
Take Colcrys by mouth with or without food, exactly as directed by your doctor. Dosing recommendations will vary and differ depending on the patient's medical condition, other drugs/foods you may be taking, and response to treatment.
If your doctor directs you to take Colcrys, use it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.
Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream. If you are taking this medication to treat symptoms due to familial Mediterranean fever, tell your doctor if your condition does not improve or if it worsens.
Taking more than the recommended dose may not increase this drug's effectiveness and may increase your risk for side effects.
Cautions
- Do not share this medication with others.
- Being overweight, drinking too much alcohol, and eating certain foods may worsen gout symptoms.
- Limit alcohol intake.
- Avoid foods high in purines that may worsen gout (such as anchovies, bacon, beer, sardines, organ meats including liver/kidneys).
- Medical tests (such as blood tests, kidney function, liver function) may be performed periodically to monitor your progress or check for side effects.
Side Effects
All medications may cause side effects, but usually patients have no, or minor, side effects. Common side effects may include:
- Nausea or vomiting
- Abdominal pain
- Diarrhea
- Hair loss
- Weakness
- Nerve irritation
One of the most worrisome side effects of Colcrys is that it can damage the bone marrow causing severe anemia, low white blood counts, and low platelets. Reduced white blood cell counts may increase the risk of infections. All patients taking Colcrys long-term require monitoring of their blood counts. Colcrys also may cause muscle pain (myopathy) or severe muscle breakdown.To reduce your risk for serious side effects, do not increase your dose, take it more frequently, or take it for a longer time than directed by your doctor. Serious side effects may occur even at usual prescribed doses. The above noted side effects may not require medical attention and may slowly decrease over time as your body adjusts to the medication. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 10242
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