Proper brain biochemistry is like a symphony, with all sorts of instruments coming together in unison to create music that frames the world in a certain light. For most the preference would be for a bright light, but if any of the instruments are out of tune then the music can go sour, and the light isn’t bright at all. Depression is the result of faulty brain biochemistry, and quite often it is dopamine and serotonin that are out of tune. Trintellix is a medication that is effective for depression relief, but how long does it take Trintellix to work? 

Like most SSRI medications, people taking Trintellix can expect to feel better within 2 to 3 weeks of starting on the medication. It may take slightly longer for some, but that’s a fairly reliable timeline for how long does Trintellix take to work. Sleep difficulties related to depression, including insomnia or hypersomnia, make take longer to resolve but nearly everyone taking Trintellix says the improvements to their mood, energy, and positivity are quite profound and occur quickly once they’re on the medication.  

People taking Zoloft for depression but are experiencing sexual side effects may have their doctor advise them to switch over to Trintellix. Many users taking Vortioxetine (active ingredient in Trintellix) report less of the negative sexual side effects that tend to affect men more often when using certain SSRIs. This has nothing to do with how long does Trintellix take to work, but it’s something to consider if you’d like to talk to your physician about changing antidepressants and getting one that is a little easier on your physiologically.  

CBT & Eat Better 

Continuing with this look at how long does Trintellix take to work, there are always things people can do to improve the effectiveness of antidepressant medication. One of the most beneficial has always been to engage in psychotherapy with cognitive behavioral therapy, and regular daily positive self-affirmations can be super helpful too. It’s also good to improve your diet if you are not eating healthily already, and remember that eating processed foods isn’t good for brain health in any way. Try to lower cholesterol too.  

Another aspect that is key for getting the maximum results from treatment for depression with Trintellix is to ensure you don’t miss any of your doses. Missing one day is okay, but if you miss two consecutive days of taking your medication you are going to suffer for it. This is connected to how long does Trintellix take to work too, and if you are forgetful it is understandable but it may be a good idea to use a smartphone medication reminder app that will give you an audible alert and screen notification that you need to take your medication.  

That’s all there is for us to say related to how long does it take Trintellix to work. Most people can expect to feel at least somewhat better within 3 weeks, and that may mean that some of those instruments in the symphony are starting to come back into tune. That will likely be music between their ears.