What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Zydelig (Idelalisib)
Prescription Required
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Product Details
Description
Your oncologist may prescribe Zydelig to treat specific blood cancers, notably chronic lymphocytic leukemia (CLL), B-cell non-Hodgkin lymphoma (HL), or relapsed small lymphocytic lymphoma (SLL).
It belongs to the class of drugs called phosphoinositide 3-kinase (PI3K) inhibitors, which target specific enzymes crucial for cancer cell growth and survival. By inhibiting these enzymes, Zydelig aids in slowing disease progression and enhancing patient outcomes.
Fact Table
Formula
C22H18FN7O
License
US FDA, EMA
Bioavailability
N/A (rapidly metabolized to active form)
Legal status
Prescription only (?)
Chemical Name
8-[6-(3-hydroxy-1H-indazol-4-yl)quinazolin-2-yl]isoquinolin-1-one
Elimination half-life
8.2 hours (Idelalisib), 10.5 hours (active metabolite GS-563117)
Dosage (Strength)
100 mg, 150 mg tablets
Pregnancy
Not recommended
Brands
Zydelig
Protein binding
93% (Idelalisib), 99% (active metabolite GS-563117)
PubChem CID
11625857
MedlinePlus
a614029
ChEBI
CHEBI:85992
ATC code
L01XX47
DrugBank
DB08930
KEGG
D10235
Routes of administration
Oral
Directions
The usual dosage of Zydelig is 150 mg by mouth twice daily. Consult your physician before stopping, starting, or changing the dosage.
Ingredients
The active ingredient in Zydelig is idelalisib.
Interactions
Tell your doctor and pharmacist if you are taking any of the following:
- Alfuzosin
- Alprazolam
- Colchicine
- Conivaptan
- Dihydroergotamine
- Dronedarone
- Eletriptan
- Eliglustat
- Eplerenone
- Ergotamine
- Finerenone
- Gepirone
- Isavuconazonium Sulfate
- Ivabradine
- Lomitapide
- Lovastatin
- Lurasidone
- Maraviroc
- Mavacamten
- Naloxegol
- Pacritinib
- Pimozide
- Ranolazine
- Silodosin
- Simvastatin
- Tolvaptan
- Triazolam
- Ubrogepant
- Venetoclax
- Voclosporin
Cautions
Zydelig may lead to skin reactions; if severe, discontinue usage and promptly inform your healthcare provider.
Regular monitoring of blood cell levels is important when starting this drug and during treatment.
Avoid Zydelig if pregnant, planning pregnancy, or breastfeeding.
Discuss your entire medication list with your pharmacist and doctor due to potential drug interactions.
Tell your doctor about kidney or liver problems before starting Zydelig.
Do not take Zydelig if you have a history of severe hypersensitivities (allergic reactions), including skin reactions.
Side Effects
Common adverse reactions to Zydelig may include:
- Anaphylaxis
- Colitis
- Cough
- Cytomegalovirus infection
- Diarrhea
- Drug reaction with eosinophilia and systemic symptoms (DRESS)
- Erythroderma
- Fatigue
- Febrile neutropenia
- Fever
- Hepatotoxicity, serious or fatal
- Hypersensitivity reaction
- Increased liver enzymes
- Infectious disease
- Nausea
- Neutropenia, All Grades
- Neutropenia, Grade 3 or 4
- Perforation of intestine
- Pneumocystis jirovecii present
- Pneumonia
- Pneumonitis
- Rash
- Sepsis
- Shivering
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
References
Zydelig [package insert]. Foster City, CA: Gilead; July 2014.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 14633
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