What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Vyzulta (Latanoprostene Bunod)

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Brand

Vyzulta (Latanoprostene Bunod)

Prescription Required

Strength
Qty
0.024% / 5ml

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  • Product Details

    Description

    VYZULTA (Latanoprostene bunod) is an ophthalmic (eye drop) medication used to reduce pressure in the fluid of the eyes (intraocular pressure) in patients with either ocular hypertension or open-angle glaucoma.

    When VYZULTA eye drops are applied, the active ingredient is split into two active moieties: latanoprost and butanediol mononitrate.

    Latanoprost increases the amount of aqueous humor (fluid in the eye) that exits the eye, contributing to the lowering of ocular pressure. Butanediol mononitrate releases nitric oxide, which relaxes the trabecular meshwork.


    Fact Table

    Formula

    C27H41NO8

    License

    US DailyMed

    Bioavailability

    -

    Legal status

    Rx-Only

    Chemical Name

    Latanoprostene bunod

    Elimination half-life

    1.8–4.6 hours

    Dosage (Strength)

    0.024%/5ml

    Pregnancy

    Not Recommended

    Brands

    Vyzulta

    Protein binding

    -

    PubChem CID

    11156438

    MedlinePlus

    a618001

    ChEBI

    177703

    ATC code

    S01EE06

    DrugBank

    DB11660

    KEGG

    D10441

    Routes of admsinistration

    Eye drop

    Directions

    Apply one drop to the affected eye (s) once daily.

    If you are using VYZULTA with other eye drops, separate them by at least 5 minutes.

    Ingredients

    The active ingredient in VYZULTA is latanoprostene bunod.

    Inactive ingredients include benzalkonium chloride, citric acid, EDTA, glycerin, polysorbate 80, sodium citrate, and water.

    Cautions

    Prostaglandin analogs like VYZULTA may cause changes in the color of the iris and eyelid. VYZULTA increases the amount of melanin in the affected tissue, causing a darkening of the eye. The changes are often permanent, and most likely to affect those with lighter colored eyes. Color change may take months or years to become apparent.

    VYZULTA may change the length and thickness of eyelashes. Eyelashed return to normal after stopping VYZULTA.

    Do not touch the tip of the applicator to the surface of the eye or other non-sterile surfaces. Doing so may contaminate the product and lead to an infection of the eye.

    Remove contact lens 15 minutes before applying VYZULTA.

    Side Effects

    The most common adverse effects of VYZULTA include:

    • Conjunctival edema
    • Conjunctival hyperemia
    • Conjunctival irritation
    • Eye irritation
    • Eye pain
    • Foreign body sensation
    • Instillation site pain
    • Ocular hyperemia
    • Punctate keratitis

    References

    1. Vyzulta. [package insert] Bridgewater, NJ: Valeant Pharmaceuticals; 2017.

    Frequently Asked Questions about Vyzulta


    What is Vyzulta used for?

    Vyzulta is indicated for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.


    What are the side effects of Vyzulta?

    Vyzulta can cause some common side effects like puffy eyelids, mild pain, blurred vision, and feeling like something's in your eye. Less common ones include eye irritation and swelling. Rare side effects include changes in vision, eye pain, and sensitivity to light. Serious side effects include severe discomfort, redness, sudden vision changes, or severe pain, which need medical attention.


    Why is Vyzulta so expensive?

    The cost of medications can vary based on factors such as research and development, production, marketing, and distribution.


    Is Vyzulta a beta blocker?

    No, Vyzulta is not a beta blocker. It is a prostaglandin F2a analogue that targets both pathways for IOP reduction.


    Does Vyzulta need to be refrigerated?

    Vyzulta should be stored at room temperature, between 15°C and 25°C (59°F and 77°F). Avoid freezing or refrigerating it.


    How much does Vyzulta lower eye pressure?

    The extent of IOP reduction varies among individuals. Vyzulta helps lower eye pressure by working on two pathways in the eye. In studies, it lowered eye pressure by around 7.5 to 9.1 mmHg in people with an average starting eye pressure of 26.7 mmHg.


    Is Vyzulta the same as latanoprost?

    Vyzulta contains latanoprostene bunod, which is a modified form of latanoprost. While they both lower IOP, Vyzulta has a dual mechanism of action.


    How long can you use Vyzulta?

    The duration of Vyzulta use depends on your specific condition and your doctor’s recommendations. Regular follow-ups with your ophthalmologist are essential.


    Who should not use Vyzulta?

    Vyzulta shouldn't be used by people allergic to it, as it can cause serious reactions like hives or trouble breathing. If someone has certain eye issues, like swelling, infections, or past surgeries, they should tell their doctor before using Vyzulta. It's not clear if it's safe during pregnancy or breastfeeding, so it's important to talk to a doctor if you're in that situation. It's not for anyone under 16. Also, it might gradually change eye color or eyelids and lashes, usually making them more brown, and this change could stick even after stopping treatment.



    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 13213

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