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Trijardy XR is a combination of three diabetes medications: Jardiance (empagliflozin), Tradjenta (linagliptin), and metformin hydrochloride (HCl). Trijardy XR is used with diet and exercise to lower A1C in adults with type 2 diabetes.
Fact Table |
|
Formula |
C24H25FO5S |
License |
US DailyMed, EU EMA |
Bioavailability |
65% |
Legal status |
Rx-Only |
Chemical Name |
Empagliflozin/Linagliptin/Metformin HCI |
Elimination half-life |
10–13 hours |
Dosage (Strength) |
12.5mg / 2.5mg / 1000mg, 5mg / 2.5mg / 1000mg, 10mg / 5mg / 1000mg, 25mg / 5mg / 1000mg |
Pregnancy |
Not recommended |
Brands |
Trijardy XR |
Protein binding |
99% |
PubChem CID |
24812758 |
MedlinePlus |
a613033 |
ChEBI |
73274 |
ATC code |
A10BK02 |
DrugBank |
DB08907 |
KEGG |
D09592 |
Routes of administration |
Inhalation |
Trijardy XR (empagliflozin, linagliptin, and metformin hydrochloride extended-release) is available in the following oral tablet strengths:
extended-release
Your starting dose will depend on your current treatment and kidney function.
Take Trijardy XR by mouth once daily with a morning meal. Swallow the tablet whole. Do not take more than 25 mg empagliflozin, 5 mg linagliptin, and 2000 mg metformin HCl.
Trijardy XR contains the following active ingredients: empagliflozin, linagliptin, and metformin hydrochloride.
Do not take Trijardy XR if you have severe kidney problems, end-stage kidney disease, or if you are on dialysis.
Do not take Trijardy XR if you have metabolic acidosis such as diabetic ketoacidosis.
Do not take Trijardy XR if you are allergic to empagliflozin, linagliptin, metformin, or any of its other ingredients.
WARNING: LACTIC ACIDOSIS See full prescribing information for complete boxed warning.
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Like with any medication, Trijardy XR has the potential to cause side effects including but not limited to constipation, diarrhea, headache, stomach and intestinal inflammation, stuffy or runny nose, sore throat, upper respiratory tract infection, and urinary tract infection.
Call your doctor right away if you develop side effects that bother you or won't go away.
Dr. Muncy (PharmD) studied science and education as an undergraduate before attending the Appalachian College of Pharmacy where she completed her PharmD in three years. She is currently using her pharmacy and healthcare expertise to write medical content for clients all around the world. She is focused on delivering the most current, accurate, and engaging information to healthcare professionals and patients. Read More....