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What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Simbrinza Opthalmic (Brinzolamide/Brimonidine Tartrate)
Also Known as Simbrinza Ophthalmic Suspension
Generic Equivalent - Simbrinza Opthalmic (Brinzolamide/Brimonidine Tartrate)
Prescription Required
Strength
Qty
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Related Products & Conditions
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Product Details
Description
Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2% is an eye drop used to decrease intraocular pressure in patients diagnosed with open-angle glaucoma or increased fluid pressure in the eye.
Fact Table
Formula
Brinzolamide: C12H21N3O5S3 Brimonidine: C11H10BrN5
License
EU EMA, US DailyMed
Bioavailability
Brinzolamide: Absorbed systemically, but below detectable levels (less than 10 ng/mL) Brimonidine: Not Available
Legal status
Prescription only
Chemical Name
Brinzolamide/Brimonidine Tartrate
Elimination half-life
111 days (Brinzolamide), Brimonidine: 3 hours (ocular), 12 hours (topical)
Dosage (Strength)
1% / 0.2% 5ml
Pregnancy
Consult Doctor
Brands
Simbrinza Opthalmic
Protein binding
60%
PubChem CID
68844
MedlinePlus
a601233
ChEBI
3176
ATC code
S01EC04
DrugBank
DB01194
KEGG
D00652
Routes of administration
Ophthalmic
Directions
Follow your doctor's instructions and carefully read the information that comes with your Simbrinza prescription to ensure that you know how and when to administer the eye drops. If you have further questions, ask your doctor or pharmacist.
If you wear contact lenses, remove them before using Simbrinza. You may put them back in 15 minutes after Simbrinza use.
Do not let the tip of the bottle touch any surface.
Before instilling the eye drops, shake the bottle well. Place one drop in the affected eye(s) three times a day. If you use other eye drops, wait at least 5 minutes before using them.
Ingredients
Simbrinza contains two active ingredients-brinzolamide and brimonidine tartrate. Boric acid, carbomer 974P, mannitol, propylene glycol, purified water, sodium chloride, and tyloxapol are the inactive ingredients. Benzalkonium chloride is added as a preservative and hydrochloric acid and/or sodium hydroxide may be added to balance the pH.
Contraindications
Patients who are allergic to brinzolamide, brimonidine tartrate, or any of the other ingredients in the medication should not use Simbrinza.
Newborns and infants younger than 2 years old should not use Simbrinza.
Cautions
- Before starting treatment with Simbrinza, inform your doctor of the following:
- All the medications you take
- Any allergies you may have
- Your medical history and active health problems
- If you are pregnant or plan to become pregnant
- If you are breastfeeding or plan to breastfeed
- Brinzolamide, one of the active ingredients in Simbrinza, is a sulfonamide. Allergic reactions that may be severe can occur in patients who are allergic to sulfonamides. Seek medical care right away if you have trouble breathing, swelling, a rash, or other skin reaction.
- Swelling of the cornea can occur in patients with low endothelial cell counts while using Simbrinza.
- Brinzolamide, one of the active ingredients in Simbrinza, and its metabolite are excreted by the kidney; therefore, use of Simbrinza should be avoided in patients with severe kidney problems.
- Other therapies along with medications that lower fluid pressure in the eye(s) should be used to treat acute angle-closure glaucoma. The use of Simbrinza has not been studied in patients who have been diagnosed with acute angle-closure glaucoma.
- Caution should be used in patients with severe heart disease.
- Caution should be used in patients with severe liver problems because brimonidine tartrate, one of the active ingredients in Simbrinza, has not been studied in these patients.
- Caution should be used in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, low blood pressure upon standing, or thromboangitis obliterans because brimonidine tartrate, one of the active ingredients in Simbrinza, can cause syndromes related to vascular insufficiency.
Side Effects
Blurred vision, eye irritation, altered taste, dry mouth, and eye allergy are the most common side effects associated with the use of Simbrinza eye drops. These are not all the Simbrinza side effects, so be sure to let your doctor know if you have side effects that are bothersome or won't go away.
Reference:
Simbrinza (brinzolamide/brimonidine tartrate ophthalmic suspension) 1%/0.2%. Fort Worth, TX: Alcon Laboratories, Inc; 2021.
Popular Questions
The PubChem CID for Brinzolamide in Simbrinza is 68844. PubChem CID is a unique identifier for chemical substances and helps in retrieving detailed chemical information.
The KEGG identifier for Brinzolamide in Simbrinza is D00652. KEGG provides information on the drug's role in metabolic pathways and its interactions, which is valuable for scientific research.
Some of the inactive ingredients in Simbrinza include boric acid, carbomer 974P, mannitol, propylene glycol, purified water, sodium chloride, and tyloxapol. Benzalkonium chloride is added as a preservative, and hydrochloric acid and/or sodium hydroxide may be added to balance the pH. Inactive ingredients can affect the formulation's stability, efficacy, and potential for causing allergic reactions.
SIMBRINZA, a combination eye drop containing brinzolamide and brimonidine tartrate, is used to lower intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. Clinical studies have shown that SIMBRINZA can reduce IOP by approximately 21-35% from baseline levels. The exact amount of pressure reduction can vary depending on the individual patient's response to the medication.
The formula of Brinzolamide in Simbrinza is C12H21N3O5S3. Knowing the chemical formula can help you understand the molecular composition and potential interactions with other medications.
The formula of Brimonidine in Simbrinza is C11H10BrN5. This information is essential for understanding the active ingredients and their pharmacological effects.
The dosage strength of Simbrinza is 1% Brinzolamide and 0.2% Brimonidine tartrate. Accurate dosage information ensures proper administration and effectiveness of the medication.
Simbrinza is administered ophthalmically, meaning it is applied directly to the eye. This method is effective for targeting the area of treatment and reducing systemic side effects.
The elimination half-life of Brinzolamide in Simbrinza is 111 days. A longer half-life means the drug stays in the system longer, which could affect dosing frequency and monitoring.
View allThe elimination half-life of Brimonidine in Simbrinza when applied ocularly is 3 hours. Understanding half-life helps in planning the dosing schedule to maintain therapeutic levels.
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13205
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