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What is a Generic Drug?
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Silenor (Doxepin)
Prescription Required
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Product Details
Description
Silenor is a prescription medication used to treat insomnia in people who have trouble staying asleep.
Silenor comes in unscored 3 mg and 6 mg tablets for oral administration.
Fact Table
Formula
C19H21NO
License
US FDA
Bioavailability
>55%
Legal status
Rx-only
Chemical Name
Doxepin
Elimination half-life
8–24 hours
Dosage (Strength)
3 mg, 6 mg tablets (for insomnia); higher doses available for other indications
Pregnancy
Use only if clearly needed (consult physician)
Brands
Silenor, Sinequan, Adapin, Zonalon (topical)
Protein binding
76–85%
PubChem CID
3155
MedlinePlus
a682338
ChEBI
4631
ATC code
N06AA12
DrugBank
DB01142
KEGG
D07827
Routes of administration
Oral, Topical
Directions
Silenor should be taken exactly as prescribed by your doctor. Contact your doctor or pharmacy if you have any questions or concerns about the medication.
Recommended initial Silenor dosing
Adults: Take 6 mg by mouth once daily. Take 30 minutes before bedtime.
Elderly patients: Take 3 mg by mouth once daily. Take 30 minutes before bedtime.
Do not take more than 6 mg by mouth daily. Do not take the medication within 3 hours of eating a meal.
Ingredients
Doxepin hydrochloride is the active ingredient in Silenor. Inactive ingredients include microcrystalline cellulose, colloidal silicon dioxide, and magnesium stearate. FD&C Blue No.1 is also contained in the 3 mg tablet. FD&C Yellow No. 10 and FD&C Blue No. 1 are also contained in the 6 mg tablet.
Contraindications
Do not take Silenor if you are allergic to doxepin hydrochloride or to any of the other ingredients or if you are allergic to other dibenzoxazepines.
Do not take Silenor with monoamine oxidase inhibitors.
Do not take Silenor if you have untreated narrow angle glaucoma or severe urinary retention.
Cautions
- Before you start taking Silenor, tell your doctor about:
- All the medications you take
- Your allergies
- Your current health conditions and past medical history
- Your pregnancy or breastfeeding status
- Behavioral changes, including “sleep-driving” and hallucinations, may occur with Silenor use.
- Depression may worsen or suicidal thoughts may occur with Silenor use.
- Do not drive, operate heavy machinery, or participate in other potentially hazardous activities until you know how the medication affects you.
- Do not take Silenor with alcohol.
- Taking Silenor with other CNS depressants or antihistamines may enhance sedative effects, possibly warranting a dose reduction.
- Silenor is not recommended for use in patients with severe sleep apnea.
Side Effects
Sleepiness, sedation, nausea, and upper respiratory tract infection are common Silenor side effects; however, these are not all the side effects that can occur. Call your doctor immediately if you have side effects that worry you or will not resolve.
You can buy Silenor for sleep online at a competitive price and with a valid prescription from your doctor at Canada Pharmacy.
Reference:
Silenor. Morristown, NJ: Currax™ Pharmaceuticals LLC; 2020.
Popular Questions
Doxepin, a tricyclic antidepressant, can cause several negative effects, including drowsiness, dry mouth, blurred vision, constipation, and weight gain. It may also lead to more serious side effects like confusion, urinary retention, or an increased risk of suicidal thoughts, particularly in young adults. Patients should be monitored for these effects and consult their healthcare provider for any concerning symptoms.Doxepin is considered a high-risk medication primarily because of its potential for causing significant side effects, particularly in elderly patients. It can lead to sedation, confusion, and increased risk of falls, as well as cardiovascular issues like arrhythmias. Additionally, it has a narrow therapeutic index, meaning there is a small margin between therapeutic and toxic doses, increasing the risk of overdose.View all
IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.Product Code : 13779
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