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Coreg CR (Carvedilol ER)

Brand

Coreg CR (Carvedilol ER)

Prescription Required

Strength
Qty
10mg
20mg
40mg
80mg
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Generic Equivalent - Coreg CR (Carvedilol ER)

Prescription Required

Strength
Qty
10mg
20mg
40mg
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  • Related Products & Conditions

  • Product Details

    Description

    Coreg CR is a prescription medication used to treat heart failure and high blood pressure, and to reduce cardiovascular death in clinically stable patients who've had a heart attack and have a left ventricular ejection fraction of 40% or less.

    Coreg CR is an extended-release medication, meaning the medication stays in the body longer. Coreg CR is available in 10 mg, 20 mg, 40 mg, and 80 mg oral capsules.

    The generic for Coreg CR is carvedilol phosphate extended-release.


    Fact Table

    Formula

    C24H26N2O4

    License

    US DailyMed

    Bioavailability

    25–35%

    Legal status

    Rx-Only

    Chemical Name

    Carvedilol

    Elimination half-life

    7–10 hours

    Dosage (Strength)

    10mg, 20mg, 40mg, 80mg

    Pregnancy

    Consult Doctor

    Brands

    Coreg

    Protein binding

    98%

    PubChem CID

    2585

    MedlinePlus

    a697042

    ChEBI

    3441

    ATC code

    C07AG02

    DrugBank

    DB01136

    KEGG

    D00255

    Routes of administration

    By mouth

    Directions

    The information that comes with your Coreg CR prescription should be carefully read. Take the medication exactly as your doctor has prescribed. Tell your doctor or pharmacist if you have any questions or concerns. Do not abruptly stop taking Coreg CR as this can worsen chest pain or cause a heart attack or irregular heart rhythms.

    Because Coreg CR is an extended-release medication, it's generally taken once daily in the morning with food. Your dose will be based on the condition being treated as well as your medical history and current health problems. 

    The capsules should be swallowed whole. Do not crush or chew the capsules. Patients who are unable to swallow the capsules may open them and sprinkle the contents over a spoonful of applesauce and consumed right away.

    Ingredients

    Carvedilol phosphate, a beta-adrenergic blocking agent with alpha-1 blocking properties, is the active ingredient in Coreg CR.

    Contraindications

    Coreg CR may not be right for everyone. 

    Coreg CR should not be taken if you have any of the following conditions:

    • Bronchial asthma or other related conditions
    • Second- or third-degree AV block
    • Sick sinus syndrome
    • Severely low heart rate and no permanent pacemaker in place
    • Cardiogenic shock or decompensated heart failure that requires IV inotropic therapy
    • Severe liver problems
    • A previous allergy or reaction to Coreg CR or any of its components

    Cautions

    Before you start taking Coreg CR, tell your doctor about:

    • All the prescription and over-the-counter medications you take
    • Your allergies
    • Your medical history and health problems
    • Your pregnancy or breastfeeding status
    • Coreg CR is a beta-adrenergic blocking agent that works to lessen the stress from your heart and blood vessels, leading to lower heart rate and blood pressure. Caution should be used when standing from a sitting position. Avoid driving or other hazardous activities until you know how the medication affects you.
    • Heart failure or fluid retention may worsen with Coreg CR dosage increases. Contact your doctor immediately if you have swelling, trouble breathing, or unexplained rapid weight gain.
    • Coreg CR may mask the symptoms of low blood sugar, including rapid heart rate. Diabetic patients should monitor their blood sugar regularly and treat it as directed by their doctor.
    • Coreg CR can cause or worsen the symptoms of slowed or stopped blood flow through the arteries in patients who have peripheral vascular disease. Use caution.
    • Although rare, Coreg CR can worsen kidney function. The risk may be greater in patients who have low blood pressure, ischemic heart disease, diffuse vascular disease, and/or underlying kidney problems.
    • Caution should be used before undergoing major surgery.
    • Coreg CR may mask the signs of overactive thyroid, or hyperthyroidism. In addition, abruptly stopping Coreg CR may worsen the symptoms of hyperthyroidism or cause a thyroid storm.
    • Patients with pheochromocytoma should use caution when taking Coreg CR.
    • Patients with Prinzmetal's variant angina should use caution when taking Coreg CR.
    • Because Coreg CR is also an alpha-blocker, the risk of Intraoperative Floppy Iris Syndrome can occur during cataract surgery.
    • Coreg CR can cause severe allergic reactions, including trouble breathing; swelling of the lips, throat, and tongue; and rash. Patients should seek emergency care right away if any of these effects occur.

    Side Effects

    Like all medications, Coreg CR has the potential to cause side effects. These include weakness, fatigue, low heart rate, low blood pressure, headache, and dizziness. However, these are not all the side effects that can occur with Coreg CR. You should contact your doctor right away if you develop side effects that bother you or won't go away.

    Reference:

    1. Coreg CR-carvedilol phosphate capsule, extended release. GlaxoSmithKline LLC; 2020.


    Questions & Answers
    avatar
    Popular Questions

    4 months ago
    4 months ago
    Coreg CR is available in 10 mg, 20 mg, 40 mg, and 80 mg oral capsules. Offering multiple strengths allows for tailored dosing based on individual patient needs and medical conditions.
    0 | 0
    4 months ago
    4 months ago
    Patients who cannot swallow Coreg CR capsules may open them and sprinkle the contents over a spoonful of applesauce to be consumed right away. This flexibility ensures that patients who have difficulty swallowing can still take their medication effectively.
    0 | 0
    4 months ago
    4 months ago
    Carvedilol extended-release should be taken once daily, preferably in the morning with food to enhance absorption and reduce the risk of side effects. It's important for patients to follow their healthcare provider's specific instructions regarding the timing and dosage. Always consult a healthcare professional for personalized advice.
    0 | 0
    4 months ago
    4 months ago
    Carvedilol is a beta-blocker used to treat high blood pressure and heart failure. The extent to which it lowers blood pressure can vary depending on the individual and the dosage prescribed. On average, carvedilol can reduce systolic blood pressure by about 10-20 mmHg and diastolic pressure by 5-15 mmHg, but the exact effect should be monitored by a healthcare provider to tailor the treatment to the patient's needs.
    0 | 0
    4 months ago
    4 months ago
    Coreg (carvedilol) is a medication primarily used to treat high blood pressure and heart failure. While it is not commonly associated with direct effects on the eyes, some people may experience side effects like blurred vision or dry eyes. If you notice any eye-related symptoms while taking Coreg, it's important to consult with your healthcare provider.
    0 | 0
    4 months ago
    4 months ago
    The elimination half-life of Coreg CR is between 7 to 10 hours, meaning it takes this amount of time for the concentration of the drug in the body to reduce by half, allowing for once-daily dosing.
    0 | 0
    4 months ago
    4 months ago
    Diabetic patients should monitor their blood sugar regularly while taking Coreg CR, as it may mask symptoms of low blood sugar like rapid heart rate. This is important for maintaining effective diabetes management.
    0 | 0
    4 months ago
    4 months ago
    Coreg CR's extended-release formulation means the medication stays in the body longer, allowing for once-daily dosing, which improves compliance and maintains stable blood levels throughout the day.
    0 | 0
    4 months ago
    4 months ago
    Caution should be used before undergoing major surgery while taking Coreg CR, as it may affect heart function and blood pressure regulation during the procedure. This consideration helps prevent surgical complications related to the medication's effects.
    0 | 0
    4 months ago
    4 months ago
    Carvedilol is a medication commonly used to treat high blood pressure and heart failure. The main side effect of carvedilol is dizziness, which often occurs due to its blood pressure-lowering effects. Other common side effects include fatigue, hypotension, and bradycardia.
    0 | 0
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    IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

    Product Code : 9742

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